prikaz prve stranice dokumenta Multistep pathogenesis of chronic myelomonocytic leukemia in patients
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Multistep pathogenesis of chronic myelomonocytic leukemia in patients
European Journal of Haematology, 109 (2022), 1; 50-57. https://doi.org/10.1111/ejh.13768
Geissler, Klaus; Jäger, Eva; Barna, Agnes; Gurbisz, Michael; Marschon, Renate; Graf, Temeida; Nösslinger, Thomas; Pfeilstöcker, Michael; Machherndl‐Spandl, Sigrid; Stauder, Reinhard; Zebisch, Armin; Sill, Heinz; Öhler, Leopold; Kušec, Rajko; Hoermann, Gregor; Valent, Peter Više autora...

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Geissler, K., Jäger, E., Barna, A., Gurbisz, M., Marschon, R., Graf, T. ... Valent, P. (2022). Multistep pathogenesis of chronic myelomonocytic leukemia in patients. European Journal of Haematology, 109. (1), 50-57. doi: 10.1111/ejh.13768

Geissler, Klaus, et al. "Multistep pathogenesis of chronic myelomonocytic leukemia in patients." European Journal of Haematology, vol. 109, br. 1, 2022, str. 50-57. https://doi.org/10.1111/ejh.13768

Geissler, Klaus, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Thomas Nösslinger, et al. "Multistep pathogenesis of chronic myelomonocytic leukemia in patients." European Journal of Haematology 109, br. 1 (2022): 50-57. https://doi.org/10.1111/ejh.13768

Geissler, K., et al. (2022) 'Multistep pathogenesis of chronic myelomonocytic leukemia in patients', European Journal of Haematology, 109(1), str. 50-57. doi: 10.1111/ejh.13768

Geissler K, Jäger E, Barna A, Gurbisz M, Marschon R, Graf T, i sur.. Multistep pathogenesis of chronic myelomonocytic leukemia in patients. European Journal of Haematology [Internet]. 07.2022. [pristupljeno 11.07.2024.];109(1):50-57. doi: 10.1111/ejh.13768

K. Geissler, et al., "Multistep pathogenesis of chronic myelomonocytic leukemia in patients", European Journal of Haematology, vol. 109, br. 1, str. 50-57, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:274303. [Citirano: 11.07.2024.]

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Naslov (engleski)Multistep pathogenesis of chronic myelomonocytic leukemia in patients
AutorKlaus Geissler
AutorEva Jäger
AutorAgnes Barna
AutorMichael Gurbisz
AutorRenate Marschon
AutorTemeida Graf
AutorThomas Nösslinger
AutorMichael Pfeilstöcker
AutorSigrid Machherndl‐Spandl
AutorReinhard Stauder
AutorArmin Zebisch
AutorHeinz Sill
AutorLeopold Öhler
AutorRajko Kušec
AutorGregor Hoermann
AutorPeter Valent
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: A multistep pathogenesis of myeloid leukemia including mutations in epigenetic, spliceosome, and signaling genes has been recently demonstrated in a preclinical model but is poorly validated in patients. ----- Methods: Clinical, phenotypic, and biologic features were compared between three distinct molecularly defined CMML cohorts including TET2 monomutated patients (T, n = 10), TET2/SRSF2 bimutated patients (TS, n = 19), and patients who had NRAS mutations in addition to TET2/SRSF2 comutations (TSN, n = 14). ----- Results: Median survival was 90, 45, and 9 months, respectively (p = .001). Whereas no patient in the T and TS group transformed into acute myeloid leukemia (AML), 6/14 patients in the TSN group had AML at study entry or transformed during follow-up. Leukocyte counts, blast cell counts, and LDH levels were significantly higher in TSN vs. TS and T, respectively, whereas hemoglobin and platelet values were not significantly different. Increased growth factor-independent myeloid colony formation was restricted to TSN but not found in T and TS, respectively. The proportion of patients showing in vitro myelomonocytic skewing in T, TS, and TSN was 0%, 56%, and 100%, respectively (p = .010). ----- Conclusion: Our results demonstrate that the model of multistep pathogenesis in CMML can be recapitulated in patients regarding clinical, phenotypic, and biologic features.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Haematology
Brojčani podacivol. 109, br. 1, str. 50-57
p-ISSN0902-4441
e-ISSN1600-0609
DOIhttps://doi.org/10.1111/ejh.13768
URN:NBNurn:nbn:hr:105:274303
Datum objave publikacije2022-07
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/ejh.13768
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-09-30 09:18:55