prikaz prve stranice dokumenta Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
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Scientific paper - Original scientific paper
Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
Journal of Clinical Medicine, 11 (2022), 12; 3541. https://doi.org/10.3390/jcm11123541
Waszczuk-Gajda, Anna; Penack, Olaf; Sbianchi, Giulia; Koster, Linda; Blaise, Didier; Reményi, Péter; Russell, Nigel; Ljungman, Per; Trneny, Marek; Mayer, Jiri; Iacobelli, Simona; Kobbe, Guido; Scheid, Christof; Apperley, Jane; Touzeau, Cyrille; Lenhoff, Stig; Jantunen, Esa; Anagnostopoulos, Achilles; Paris, Laura; Browne, Paul; Thieblemont, Catherine; Schaap, Nicolaas; Sierra, Jorge; Yakoub-Agha, Ibrahim; Garderet, Laurent; Styczynski, Jan; Schoemans, Helene; Moiseev, Ivan; Duarte, Rafael F.; Perić, Zinaida; Montoto, Silvia; van Biezen, Anja; Mikulska, Malgorzata; Aljurf, Mahmoud; Ruutu, Tapani; Kröger, Nicolaus; Morris, Curly; Koenecke, Christian; Schoenland, Stefan; Basak, Grzegorz W. More authors...

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Waszczuk Gajda, A., Penack, O., Sbianchi, G., Koster, L., Blaise, D., Reményi, P. ... Basak, G. W. (2022). Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study. Journal of Clinical Medicine, 11. (12). doi: 10.3390/jcm11123541

Waszczuk Gajda, Anna, et al. "Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study." Journal of Clinical Medicine, vol. 11, no. 12, 2022. https://doi.org/10.3390/jcm11123541

Waszczuk Gajda, Anna, Olaf Penack, Giulia Sbianchi, Linda Koster, Didier Blaise, Péter Reményi, Nigel Russell, et al. "Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study." Journal of Clinical Medicine 11, no. 12 (2022). https://doi.org/10.3390/jcm11123541

Waszczuk Gajda, A., et al. (2022) 'Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study', Journal of Clinical Medicine, 11(12). doi: 10.3390/jcm11123541

Waszczuk Gajda A, Penack O, Sbianchi G, Koster L, Blaise D, Reményi P, and sur.. Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study. Journal of Clinical Medicine [Internet]. 2022 June 20 [cited 2024 October 05];11(12). doi: 10.3390/jcm11123541

A. Waszczuk Gajda, et al., "Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study", Journal of Clinical Medicine, vol. 11, no. 12, June 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:473709. [Accessed: 05 October 2024]

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Title (english)Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
AuthorAnna Waszczuk-Gajda
AuthorOlaf Penack
AuthorGiulia Sbianchi
AuthorLinda Koster
AuthorDidier Blaise
AuthorPéter Reményi
AuthorNigel Russell
AuthorPer Ljungman
AuthorMarek Trneny
AuthorJiri Mayer
AuthorSimona Iacobelli
AuthorGuido Kobbe
AuthorChristof Scheid
AuthorJane Apperley
AuthorCyrille Touzeau
AuthorStig Lenhoff
AuthorEsa Jantunen
AuthorAchilles Anagnostopoulos
AuthorLaura Paris
AuthorPaul Browne
AuthorCatherine Thieblemont
AuthorNicolaas Schaap
AuthorJorge Sierra
AuthorIbrahim Yakoub-Agha
AuthorLaurent Garderet
AuthorJan Styczynski
AuthorHelene Schoemans
AuthorIvan Moiseev
AuthorRafael F. Duarte
AuthorZinaida Perić
AuthorSilvia Montoto
AuthorAnja van Biezen
AuthorMalgorzata Mikulska
AuthorMahmoud Aljurf
AuthorTapani Ruutu
AuthorNicolaus Kröger
AuthorCurly Morris
AuthorChristian Koenecke
AuthorStefan Schoenland
AuthorGrzegorz W. Basak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). ----- Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0-100 days, 101 days-1 year, and >1 year after the first transplant. ----- Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4-108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1-7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3-5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. ----- Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 11, no. 12, 3541
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11123541
URN:NBNurn:nbn:hr:105:473709
Publication2022-06-20
Document URLhttps://www.mdpi.com/2077-0383/11/12/3541
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-05 11:48:28