Radiološki dijagnostički postupak kod inflamatornog karcinoma dojke

master's thesis

• Title (english): Imaging of inflammatory breast cancer
• Author: Mateja Varjačić
• Mentor: Maja Prutki (mentor)
• Committee member: Jasminka Jakić-Razumović (predsjednik povjerenstva)
• Committee member: Milan Radoš (član povjerenstva)
• Committee member: Maja Prutki (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Radiology); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology

Abstract

Inflamatorni karcinom dojke je rijedak i vrlo agresivan tip tumora dojke. Očituje se eritematoznom i edematoznom dojkom sa ili bez palpabilnih masa i potpuno razvijenom kliničkom slikom unutar 3 mjeseca od početka prvih simptoma. Čak 55–85% bolesnica pri postavljanu dijagnoze već ima metastaze u aksilarne ili supraklavikularne limfne čvorove, a 20-40% ih ima i udaljene metastaze najčešće u kosti, jetru, pluća ili mozak. Ukupno 5-godišnje preživljenje, unatoč agresivnoj terapiji, iznosi samo 30-40%. Zbog svega navedenog, vrlo je važno brzo i precizno postavljanje dijagnoze pri čemu radiološki dijagnostički postupci imaju veliku ulogu. Većina bolesnica sa inflamatornim karcinomom ima mamografski guste dojke koje, u kombinaciji sa edemom, daju ograničene i suptilne mamografski vidljive promjene. Ultrazvuk (UZV) je vrlo korisna, dopunska dijagnostička metoda koja bolje prikazuje inflamatorno promijenjene dojke, eventualne tumorske mase i uvećane regionalne limfne čvorove. Biopsija je nužna za dokaz malignosti, a najčešće se izvodi pod kontrolom UZV-a. Ako klinički simptomi ukazuju na inflamatorni karcinom, a mamografija i UZV ne mogu prikazati tumor niti odrediti mjesto biopsije, potrebno je učiniti magnetnu rezonanciju dojke.

Abstract (english)

Inflammatory breast cancer is a rare and very aggressive type of breast tumor. It is characterized by rapid progression, erythema and edema of the breast with or without underlying palpable mass. At presentation, 50-85% of patients will have metastases to axillary and supraclavicular lymph nodes, and 20- 40 % of them will also have distant metastases to lungs, liver, bone or brain. Overall 5-year survival, despite aggressive therapy, is still very low. Because of all of the above, imaging is very important part of managing inflammatory breast cancer. Most of the patients with inflammatory breast cancer have dense breast tissue, which, in combination with edema, may lead to poor imaging findings on mammography. Ultrasonography is good additional diagnostic method. It is better in identification of a focal breast abnormality and regional nodal involvement. Biopsy is necessary to prove malignancy and ultrasound guided biopsy is the most common technique. If clinical signs suggesting inflammatory breast cancer and mammography and ultrasound can not detect primary breast lesion, MR imaging is indicated.

• Keywords: inflamatorni karcinom dojke; radiološka dijagnostika; mamografija; ultrazvuk; magnetna rezonancija
• Keywords (english): inflammatory breast cancer; imaging; mammography; ultrasonography; magnetic resonance imaging
• Language: croatian
• URN:NBN: urn:nbn:hr:105:541907
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-04-13 10:50:17