Hiperbarična oksigenacija u liječenju Crohnove bolesti

professional thesis

• Title (english): Hyperbaric oxygenation in the treatment of Crohn's disease
• Author: Jure Krstulović
• Mentor: Hrvoje Silovski (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-09-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Crohnova bolest je kronična, panintestinalna, transmuralna, nespecifična, granulomatozna upalna bolest još nerazjašnjene etiologije i patogeneze te teško predvidivog tijeka i prognoze. U svjetskoj se literaturi hiperbarična oksigenoterapija (HBOT) kao dodatna terapija u liječenju ove bolesti prvi puta spominje 1962. godine, te danas postoji više značajnih istraživanja o korisnosti HBO-a u liječenju Crohnove bolesti. Učinci HBOTa temelje se na poboljšanju mikrocirkulacije,, antimik-robnom i antiedematoznom djelovanju. Naš stručni rad opisuje primjenu hiperbarične oksigenacije kao dodatne terapije u konzervativnom liječenju kod Crohnove bolesti, kao i korist primjene HBOta u ranom poslijeoperacijskom razdoblju s ciljem prevencije kirurških infekcija, te pospje-šenja gastrointestinalnog motiliteta. Rad opisuje ishode liječenja kod 61 uzastopnog bolesnika bo-lesnika s Crohnovom bolesti tankog i debelog crijeva u petogodišnjem periodu. Svi su bolesnici liječeni i hiperbaričnom oksigenacijom (HBOT) kao potpornom metodom. Rezultati su uspoređeni s bolesnicima iz prethodnog razdoblja kod kojih nije korištena HBOT. Naše iskustvo pokazuje da je HBOT korisna u odlaganju ili izbjegavanju operacijskog liječenja,a kod operiranih bolesnika ubrzava poslijeoperacijski oporavak i smanjuje mogućnost pojave poslijeoperacijskih komplika-cija. Iako postoji već nekoliko preglednih radova s meta analizama vezanih za HBOT u terapiju upalnih bolesti crijeva, a za potpuno vrednovanje metode kod Crohnove bolesti nužna su daljnja prospektivna i randomizirana klinička istraživanja na većem broju ispitanika.

Abstract (english)

Crohn's disease is a chronic, panintestinal, transmural, nonspecific, granulomatous inflammatory disease with still unexplained etiology and pathogenesis and it is difficult to predict the course and prognosis of the disease. In the literature, hyperbaric oxygen therapy (HBOT) as an additional therapy in the treatment of this disease was first mentioned in 1962, and today there are several significant studies on the usefulness of HBO in the treatment of Crohn's disease. The effects of HBOT are based on the facilitation of microcirculation, antimicrobial and antiedematous effects. Our study describes the use of hyperbaric oxygenation as an additional therapy in conservative treatment of Crohn's disease, as well as the benefit of using HBOT in the early postoperative period with the aim of preventing surgical complications and improvement of gastrointestinal motility. Study describes the results of treatment in 61 consecutive patients with Crohn's disease of the small and large intestine over a five-year period. All patients were treated with hyperbaric oxygenation (HBOT) as a supportive method. The results were compared with patients from the previous period in whom HBOT was not used. Our experience shows that HBOT is useful in postponing or avoi-ding surgical treatment, and in operated patients it improves postoperative recovery and reduces the rate of postoperative complications. Although there are already several review papers with meta-analyses related to HBOT in the treatment of inflammatory bowel diseases, further prospec-tive and randomized clinical studies on a larger number of patients are required for a proper eva-luation of the method in the treatment of Crohn's disease.

• Keywords: Hiperbarična oksigenacija; Postoperativne komplikacije; Upalne bolesti crijeva; Crohnova bolest
• Keywords (english): Hyperbaric Oxygenation; Postoperative Complications; Inflammatory Bowel Diseases; Crohn's disease
• Language: croatian
• URN:NBN: urn:nbn:hr:105:894743
• Study programme: Title: Abdominal surgery; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra abdominalne kirurgije (sveučilišni/a magistar/magistra abdominalne kirurgije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-02-06 09:18:58