prikaz prve stranice dokumenta The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
  Download
PDF 144.73 KB
Scientific paper - Original scientific paper
The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
Life Sciences, 79 (2006), 1; 45-49. https://doi.org/10.1016/j.lfs.2005.12.030
Pivac, Nela; Knežević, Jelena; Mustapić, Maja ; Deželjin, Martina ; Muck-Šeler, Dorotea ; Kozarić-Kovačić, Dragica ; Balija, Melita ; Matijević, Tanja ; Pavelić, Jasminka

Cite this document

Pivac, N., Knežević, J., Mustapić, M., Deželjin, M., Muck Šeler, D., Kozarić Kovačić, D. ... Pavelić, J. (2006). The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. Life Sciences, 79. (1), 45-49. doi: 10.1016/j.lfs.2005.12.030

Pivac, Nela, et al. "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men." Life Sciences, vol. 79, no. 1, 2006, pp. 45-49. https://doi.org/10.1016/j.lfs.2005.12.030

Pivac, Nela, Jelena Knežević, Maja Mustapić, Martina Deželjin, Dorotea Muck Šeler, Dragica Kozarić Kovačić, Melita Balija, Tanja Matijević and Jasminka Pavelić. "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men." Life Sciences 79, no. 1 (2006): 45-49. https://doi.org/10.1016/j.lfs.2005.12.030

Pivac, N., et al. (2006) 'The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men', Life Sciences, 79(1), pp. 45-49. doi: 10.1016/j.lfs.2005.12.030

Pivac N, Knežević J, Mustapić M, Deželjin M, Muck Šeler D, Kozarić Kovačić D, and sur.. The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. Life Sciences [Internet]. 2006 May 30 [cited 2024 August 17];79(1):45-49. doi: 10.1016/j.lfs.2005.12.030

N. Pivac, et al., "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men", Life Sciences, vol. 79, no. 1, pp. 45-49, May 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:421717. [Accessed: 17 August 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
AuthorNela Pivac
AuthorJelena Knežević
AuthorMaja Mustapić
AuthorMartina Deželjin
AuthorDorotea Muck-Šeler
AuthorDragica Kozarić-Kovačić
AuthorMelita Balija
AuthorTanja Matijević
AuthorJasminka Pavelić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Monoamine oxidase (MAO), a mitochondrial flavine containing enzyme, exists in two isoenzymes, MAO-A and MAO-B. Platelets contain MAO-B subtype, proposed to be a biomarker for different personality characteristics and vulnerability for substance abuse. The most common polymorphism of MAO-B gene, a single base change (A or G) occurs in intron 13. It has been proposed to be a functional polymorphism, controlling the activity of MAO-B in platelets. The aim of the study was to determine the association between platelet MAO-B activity and MAO-B intron 13 polymorphism in 225 racially and ethnically uniform healthy Caucasian men of the Croatian origin. Our results showed that platelet MAO-B activity did not differ between subjects subdivided into those with A-allele or G-allele. This polymorphism of the MAO-B gene did not control the activity of the MAO-B in platelets. Platelet MAO-B activity was associated only with the smoking status, and it was significantly decreased in smokers when compared to nonsmokers. No significant association was found between MAO-B polymorphism and smoking status. In healthy individuals of the Croatian origin, the studied MAO-B polymorphism showed a lack of functional importance in regulating MAO-B activity in platelets. Since different populations may vary in the association between functional polymorphism and the MAO-B activity, and the genotype of transcription factor AP-2β was reported to be associated with altered platelet MAO-B activity, and with specific personality traits, further studies on different populations should be conducted to elucidate the molecular mechanism/s regulating platelet MAO-B activity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleLife Sciences
Numberingvol. 79, no. 1, pp. 45-49
p-ISSN0024-3205
DOIhttps://doi.org/10.1016/j.lfs.2005.12.030
URN:NBNurn:nbn:hr:105:421717
Publication2006-05-30
Document URLhttps://doi.org/10.1016/j.lfs.2005.12.030
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:02:32