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The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
Life Sciences, 79 (2006), 1; 45-49. https://doi.org/10.1016/j.lfs.2005.12.030
Pivac, Nela; Knežević, Jelena; Mustapić, Maja ; Deželjin, Martina ; Muck-Šeler, Dorotea ; Kozarić-Kovačić, Dragica ; Balija, Melita ; Matijević, Tanja ; Pavelić, Jasminka

Citirajte ovaj rad

Pivac, N., Knežević, J., Mustapić, M., Deželjin, M., Muck Šeler, D., Kozarić Kovačić, D. ... Pavelić, J. (2006). The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. Life Sciences, 79. (1), 45-49. doi: 10.1016/j.lfs.2005.12.030

Pivac, Nela, et al. "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men." Life Sciences, vol. 79, br. 1, 2006, str. 45-49. https://doi.org/10.1016/j.lfs.2005.12.030

Pivac, Nela, Jelena Knežević, Maja Mustapić, Martina Deželjin, Dorotea Muck Šeler, Dragica Kozarić Kovačić, Melita Balija, Tanja Matijević i Jasminka Pavelić. "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men." Life Sciences 79, br. 1 (2006): 45-49. https://doi.org/10.1016/j.lfs.2005.12.030

Pivac, N., et al. (2006) 'The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men', Life Sciences, 79(1), str. 45-49. doi: 10.1016/j.lfs.2005.12.030

Pivac N, Knežević J, Mustapić M, Deželjin M, Muck Šeler D, Kozarić Kovačić D, i sur.. The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. Life Sciences [Internet]. 30.05.2006. [pristupljeno 18.07.2024.];79(1):45-49. doi: 10.1016/j.lfs.2005.12.030

N. Pivac, et al., "The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men", Life Sciences, vol. 79, br. 1, str. 45-49, Svibanj 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:421717. [Citirano: 18.07.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:421717
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Podaci o radu
Naslov (engleski)The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
AutorNela Pivac
AutorJelena Knežević
AutorMaja Mustapić
AutorMartina Deželjin
AutorDorotea Muck-Šeler
AutorDragica Kozarić-Kovačić
AutorMelita Balija
AutorTanja Matijević
AutorJasminka Pavelić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Monoamine oxidase (MAO), a mitochondrial flavine containing enzyme, exists in two isoenzymes, MAO-A and MAO-B. Platelets contain MAO-B subtype, proposed to be a biomarker for different personality characteristics and vulnerability for substance abuse. The most common polymorphism of MAO-B gene, a single base change (A or G) occurs in intron 13. It has been proposed to be a functional polymorphism, controlling the activity of MAO-B in platelets. The aim of the study was to determine the association between platelet MAO-B activity and MAO-B intron 13 polymorphism in 225 racially and ethnically uniform healthy Caucasian men of the Croatian origin. Our results showed that platelet MAO-B activity did not differ between subjects subdivided into those with A-allele or G-allele. This polymorphism of the MAO-B gene did not control the activity of the MAO-B in platelets. Platelet MAO-B activity was associated only with the smoking status, and it was significantly decreased in smokers when compared to nonsmokers. No significant association was found between MAO-B polymorphism and smoking status. In healthy individuals of the Croatian origin, the studied MAO-B polymorphism showed a lack of functional importance in regulating MAO-B activity in platelets. Since different populations may vary in the association between functional polymorphism and the MAO-B activity, and the genotype of transcription factor AP-2β was reported to be associated with altered platelet MAO-B activity, and with specific personality traits, further studies on different populations should be conducted to elucidate the molecular mechanism/s regulating platelet MAO-B activity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaLife Sciences
Brojčani podacivol. 79, br. 1, str. 45-49
p-ISSN0024-3205
DOIhttps://doi.org/10.1016/j.lfs.2005.12.030
URN:NBNurn:nbn:hr:105:421717
Datum objave publikacije2006-05-30
URL dokumentahttps://doi.org/10.1016/j.lfs.2005.12.030
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 19:02:32