Optically stimulated luminescence in vivo dosimetry for radiotherapy: physical characterization and clinical measurements in (60)Co beams

Scientific paper - Original scientific paper

• Author: Iva Mrčela
• Author: Tomislav Bokulić
• Author: Joanna Izewska
• Author: Mirjana Budanec
• Author: Ana Fröbe
• Author: Zvonko Kusić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

A commercial optically stimulated luminescence (OSL) dosimetry system was investigated for in vivo dosimetry in radiation therapy. Dosimetric characteristics of InLight dot dosimeters and a microStar reader (Landauer Inc.) were tested in (60)Co beams. The reading uncertainty of a single dosimeter was 0.6%. The reproducibility of a set of dosimeters after a single irradiation was 1.6%, while in repeated irradiations of the same dosimeters it was found to be 3.5%. When OSL dosimeters were optically bleached between exposures, the reproducibility of repeated measurements improved to 1.0%. Dosimeters were calibrated for the entrance dose measurements and a full set of correction factors was determined. A pilot patient study that followed phantom validation testing included more than 100 measured fields with a mean relative difference of the measured entrance dose from the expected dose of 0.8% and the standard deviation of 2.5%. In conclusion, these results demonstrate that OSL dot dosimeters represent a valid alternative to already established in vivo dosimetry systems.

• Keywords (english): Aluminum Oxide/chemistry; Cobalt Radioisotopes/therapeutic use; Humans; Luminescent Measurements/instrumentation; Luminescent Measurements/methods; Optical Devices; Radiometry/instrumentation; Radiometry/methods; Radiotherapy/instrumentation; Radiotherapy/methods; Radiotherapy Dosage; Reproducibility of Results; Risk Assessment/methods; Sensitivity and Specificity
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Physics in Medicine and Biology
• Numbering: vol. 56, no. 18, pp. 6065-6082
• p-ISSN: 0031-9155
• DOI: https://doi.org/10.1088/0031-9155/56/18/018
• URN:NBN: urn:nbn:hr:105:915169
• Publication: 2011-09-21
• Document URL: https://doi.org/10.1088/0031-9155/56/18/018
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:12:50