Recurrent sinonasal melanoma - report of five surgical cases and short literature review

Scientific paper - Case study

• Title (croatian): Recidivirajući sinonazalni melanom - prikaz 5 slučajeva i kratki pregled literature
• Author: Davor Džepina
• Author: Livije Kalogjera
• Author: Tomislav Baudoin
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The aim of this study is to present five surgical cases of recurrent sinonasal melanoma. We report the clinical course of this highly malignant disease and give a brief overview of the relevant literature. For the purpose of our presentation, inclusion criteria for all patients were initally negative surgical margins, surgery with curative intent without implementation of radiotherapy, and absence of distant metastatic spread at presentation (MO). They were diagnosed and treated at the same ENT/Head and Neck Surgery department and had clear surgical margins following first resection. The majority of five cases had local recurrences (average two) which were all amenable to at least one salvage operation. In conclusion, despite extensive disease at presentation, we recommend repeated attempts at local surgical salvage. However, this decision must be carefully considered, respecting postoperative quality of life, the estimated life expectancy as well as general socioeconomic issues in each particular case.

Abstract (croatian)

Cilj ovog rada bio prezentirati 5 kirurških slučajeva recidivirajućeg melanoma nosa i paranazalnih sinusa, prikazati
klinički tijek ove visoko maligne bolesti te dati kratki prikaz stručne literature. Za potrebe ove prezentacije kriteriji
uključenja za sve pacijente bili su inicijalni kurativni kirurški zahvat bez implementirane radioterapije, odsutnošću udaljenih
metastaza (M0) kod prezentacije bolesti, te negativne patološke granice ekscizije. Svi slučajevi su bili dijagnosticirani
i operirani na Klinici za otorinolaringologiju te imali čiste kirurške rubove nakon prve resekcije tumora. Većina
pacijenata imala je lokalne recidive bolesti (u prosjeku dva), koji su bili dostupni najmanje jednoj operaciji. Zaključno,
unatoč lokalno proširenoj bolesti u najvećem broju slučajeva, preporučujemo pokušaj reoperacije kod pojave lokalnog
recidiva sinonazalnog melanoma. Ipak, potrebna je pažljiva i detaljna procjena prije donošenja odluke o daljnjim operacijama
recidiva, poštujući predvidjenu postoperativnu kvalitetu života, očekivanu specifičnu prognozu kao i općenito
socijalno-ekonomsko stanje pacijenta u svakom pojedinačnom slučaju.

• Keywords (english): Female; Humans; Male; Melanoma / diagnostic imaging; Melanoma / pathology; Melanoma / surgery; Middle Aged; Nose Neoplasms / diagnostic imaging; Nose Neoplasms / pathology; Nose Neoplasms / surgery; Paranasal Sinuses / diagnostic imaging; Paranasal Sinuses / pathology; Recurrence; Tomography, X-Ray Computed
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 36, no. S. 2, pp. 179-184
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:991238
• Publication: 2012-11
• Document URL: https://hrcak.srce.hr/96499
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:46:01