prikaz prve stranice dokumenta The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
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Scientific paper - Original scientific paper
The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
PLoS One, 10 (2015), 3; e0117639. https://doi.org/10.1371/journal.pone.0117639
Delahaye-Sourdeix, Manon; Oliver, Javier; Timofeeva, Maria N.; Gaborieau, Valérie; Johansson, Mattias; Chabrier, Amélie; Wozniak, Magdalena B.; Brenner, Darren R.; Vallée, Maxime P.; Anantharaman, Devasena; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsagué, Xavier; Macfarlane, Tatiana V.; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S.; Conway, David I.; Znaor, Ariana; Healy, Claire M.; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Ioan Nicolae; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Victor; Eluf-Neto, José; Boffetta, Paolo; Garrote, Leticia Fernández; Serraino, Diego; Lener, Marcin; Jaworowska, Ewa; Lubiński, Jan; Boccia, Stefania; Rajkumar, Thangarajan; Samant, Tanuja A.; Mahimkar, Manoj B.; Matsuo, Keitaro; Franceschi, Silvia; Byrnes, Graham; Brennan, Paul; McKay, James D. More authors...

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Delahaye Sourdeix, M., Oliver, J., Timofeeva, M. N., Gaborieau, V., Johansson, M., Chabrier, A. ... McKay, J. D. (2015). The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract. PLoS One, 10. (3). doi: 10.1371/journal.pone.0117639

Delahaye Sourdeix, Manon, et al. "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract." PLoS One, vol. 10, no. 3, 2015. https://doi.org/10.1371/journal.pone.0117639

Delahaye Sourdeix, Manon, Javier Oliver, Maria N. Timofeeva, Valérie Gaborieau, Mattias Johansson, Amélie Chabrier, Magdalena B. Wozniak, et al. "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract." PLoS One 10, no. 3 (2015). https://doi.org/10.1371/journal.pone.0117639

Delahaye Sourdeix, M., et al. (2015) 'The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract', PLoS One, 10(3). doi: 10.1371/journal.pone.0117639

Delahaye Sourdeix M, Oliver J, Timofeeva MN, Gaborieau V, Johansson M, Chabrier A, and sur.. The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract. PLoS One [Internet]. 2015 March 20 [cited 2024 July 18];10(3). doi: 10.1371/journal.pone.0117639

M. Delahaye Sourdeix, et al., "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract", PLoS One, vol. 10, no. 3, March 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:319918. [Accessed: 18 July 2024]

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Metadata
Title (english)The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
AuthorManon Delahaye-Sourdeix
AuthorJavier Oliver
AuthorMaria N. Timofeeva
AuthorValérie Gaborieau
AuthorMattias Johansson
AuthorAmélie Chabrier
AuthorMagdalena B. Wozniak
AuthorDarren R. Brenner
AuthorMaxime P. Vallée
AuthorDevasena Anantharaman
AuthorPagona Lagiou
AuthorIvana Holcátová
AuthorLorenzo Richiardi
AuthorKristina Kjaerheim
AuthorAntonio Agudo
AuthorXavier Castellsagué
AuthorTatiana V. Macfarlane
AuthorLuigi Barzan
AuthorCristina Canova
AuthorNalin S. Thakker
AuthorDavid I. Conway
AuthorAriana Znaor
AuthorClaire M. Healy
AuthorWolfgang Ahrens
AuthorDavid Zaridze
AuthorNeonilia Szeszenia-Dabrowska
AuthorJolanta Lissowska
AuthorEleonora Fabianova
AuthorIoan Nicolae Mates
AuthorVladimir Bencko
AuthorLenka Foretova
AuthorVladimir Janout
AuthorMaria Paula Curado
AuthorSergio Koifman
AuthorAna Menezes
AuthorVictor Wünsch-Filho
AuthorJosé Eluf-Neto
AuthorPaolo Boffetta
AuthorLeticia Fernández Garrote
AuthorDiego Serraino
AuthorMarcin Lener
AuthorEwa Jaworowska
AuthorJan Lubiński
AuthorStefania Boccia
AuthorThangarajan Rajkumar
AuthorTanuja A. Samant
AuthorManoj B. Mahimkar
AuthorKeitaro Matsuo
AuthorSilvia Franceschi
AuthorGraham Byrnes
AuthorPaul Brennan
AuthorJames D. McKay
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS One
Numberingvol. 10, no. 3, e0117639
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0117639
URN:NBNurn:nbn:hr:105:319918
Publication2015-03-20
Document URLhttps://doi.org/10.1371/journal.pone.0117639
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:10:11