prikaz prve stranice dokumenta The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
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The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
PLoS One, 10 (2015), 3; e0117639. https://doi.org/10.1371/journal.pone.0117639
Delahaye-Sourdeix, Manon; Oliver, Javier; Timofeeva, Maria N.; Gaborieau, Valérie; Johansson, Mattias; Chabrier, Amélie; Wozniak, Magdalena B.; Brenner, Darren R.; Vallée, Maxime P.; Anantharaman, Devasena; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsagué, Xavier; Macfarlane, Tatiana V.; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S.; Conway, David I.; Znaor, Ariana; Healy, Claire M.; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Fabianova, Eleonora; Mates, Ioan Nicolae; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Victor; Eluf-Neto, José; Boffetta, Paolo; Garrote, Leticia Fernández; Serraino, Diego; Lener, Marcin; Jaworowska, Ewa; Lubiński, Jan; Boccia, Stefania; Rajkumar, Thangarajan; Samant, Tanuja A.; Mahimkar, Manoj B.; Matsuo, Keitaro; Franceschi, Silvia; Byrnes, Graham; Brennan, Paul; McKay, James D. Više autora...

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Delahaye Sourdeix, M., Oliver, J., Timofeeva, M. N., Gaborieau, V., Johansson, M., Chabrier, A. ... McKay, J. D. (2015). The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract. PLoS One, 10. (3). doi: 10.1371/journal.pone.0117639

Delahaye Sourdeix, Manon, et al. "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract." PLoS One, vol. 10, br. 3, 2015. https://doi.org/10.1371/journal.pone.0117639

Delahaye Sourdeix, Manon, Javier Oliver, Maria N. Timofeeva, Valérie Gaborieau, Mattias Johansson, Amélie Chabrier, Magdalena B. Wozniak, et al. "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract." PLoS One 10, br. 3 (2015). https://doi.org/10.1371/journal.pone.0117639

Delahaye Sourdeix, M., et al. (2015) 'The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract', PLoS One, 10(3). doi: 10.1371/journal.pone.0117639

Delahaye Sourdeix M, Oliver J, Timofeeva MN, Gaborieau V, Johansson M, Chabrier A, i sur.. The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract. PLoS One [Internet]. 20.03.2015. [pristupljeno 04.07.2024.];10(3). doi: 10.1371/journal.pone.0117639

M. Delahaye Sourdeix, et al., "The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract", PLoS One, vol. 10, br. 3, Ožujak 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:319918. [Citirano: 04.07.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:319918
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Naslov (engleski)The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
AutorManon Delahaye-Sourdeix
AutorJavier Oliver
AutorMaria N. Timofeeva
AutorValérie Gaborieau
AutorMattias Johansson
AutorAmélie Chabrier
AutorMagdalena B. Wozniak
AutorDarren R. Brenner
AutorMaxime P. Vallée
AutorDevasena Anantharaman
AutorPagona Lagiou
AutorIvana Holcátová
AutorLorenzo Richiardi
AutorKristina Kjaerheim
AutorAntonio Agudo
AutorXavier Castellsagué
AutorTatiana V. Macfarlane
AutorLuigi Barzan
AutorCristina Canova
AutorNalin S. Thakker
AutorDavid I. Conway
AutorAriana Znaor
AutorClaire M. Healy
AutorWolfgang Ahrens
AutorDavid Zaridze
AutorNeonilia Szeszenia-Dabrowska
AutorJolanta Lissowska
AutorEleonora Fabianova
AutorIoan Nicolae Mates
AutorVladimir Bencko
AutorLenka Foretova
AutorVladimir Janout
AutorMaria Paula Curado
AutorSergio Koifman
AutorAna Menezes
AutorVictor Wünsch-Filho
AutorJosé Eluf-Neto
AutorPaolo Boffetta
AutorLeticia Fernández Garrote
AutorDiego Serraino
AutorMarcin Lener
AutorEwa Jaworowska
AutorJan Lubiński
AutorStefania Boccia
AutorThangarajan Rajkumar
AutorTanuja A. Samant
AutorManoj B. Mahimkar
AutorKeitaro Matsuo
AutorSilvia Franceschi
AutorGraham Byrnes
AutorPaul Brennan
AutorJames D. McKay
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS One
Brojčani podacivol. 10, br. 3, e0117639
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0117639
URN:NBNurn:nbn:hr:105:319918
Datum objave publikacije2015-03-20
URL dokumentahttps://doi.org/10.1371/journal.pone.0117639
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:10:11