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Scientific paper - Review paper

Botulinum neurotoxin type A: actions beyond SNAP-25?

Toxicology, 335 (2015); 79-84. https://doi.org/10.1016/j.tox.2015.07.003

Matak, Ivica; Lacković, Zdravko

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APA 6th Edition

Matak, I. & Lacković, Z. (2015). Botulinum neurotoxin type A: actions beyond SNAP-25?. Toxicology, 335., 79-84. doi: 10.1016/j.tox.2015.07.003

MLA 8th Edition

Matak, Ivica and Zdravko Lacković. "Botulinum neurotoxin type A: actions beyond SNAP-25?." Toxicology, vol. 335, 2015, pp. 79-84. https://doi.org/10.1016/j.tox.2015.07.003

Chicago 17th Edition

Matak, Ivica and Zdravko Lacković. "Botulinum neurotoxin type A: actions beyond SNAP-25?." Toxicology 335 (2015): 79-84. https://doi.org/10.1016/j.tox.2015.07.003

Harvard

Matak, I. and Lacković, Z. (2015) 'Botulinum neurotoxin type A: actions beyond SNAP-25?', Toxicology, 335, pp. 79-84. doi: 10.1016/j.tox.2015.07.003

Vancouver

Matak I, Lacković Z. Botulinum neurotoxin type A: actions beyond SNAP-25?. Toxicology [Internet]. 2015 September 01 [cited 2024 November 29];335:79-84. doi: 10.1016/j.tox.2015.07.003

IEEE

I. Matak and Z. Lacković, "Botulinum neurotoxin type A: actions beyond SNAP-25?", Toxicology, vol. 335, pp. 79-84, September 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:524932. [Accessed: 29 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:524932

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Metadata

Title (english)	Botulinum neurotoxin type A: actions beyond SNAP-25?
Author	Ivica Matak
Author	Zdravko Lacković
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	Botulinum neurotoxin type A (BoNT/A), the most potent toxin known in nature which causes botulism, is a commonly used therapeutic protein. It prevents synaptic vesicle neuroexocytosis by proteolytic cleavage of synaptosomal-associated protein of 25 kDa (SNAP-25). It is widely believed that BoNT/A therapeutic or toxic actions are exclusively mediated by SNAP-25 cleavage. On the other hand, in vitro and in vivo findings suggest that several BoNT/A actions related to neuroexocytosis, cell cycle and apoptosis, neuritogenesis and gene expression are not necessarily mediated by this widely accepted mechanism of action. In present review we summarize the literature evidence which point to the existence of unknown BoNT/A molecular target(s) and modulation of unknown signaling pathways. The effects of BoNT/A apparently independent of SNAP-25 occur at similar doses/concentrations known to induce SNAP-25 cleavage and prevention of neurotransmitter release. Accordingly, these effects might be pharmacologically significant. Potentially the most interesting are observations of antimitotic and antitumor activity of BoNT/A. However, the exact mechanisms require further studies.
Keywords (english)
Language	english
Publication type	Scientific paper - Review paper
Publication status	Published
Peer review	Peer review
Publication version	Accepted version
Journal title	Toxicology
Numbering	vol. 335, pp. 79-84
p-ISSN	0300-483X
DOI	https://doi.org/10.1016/j.tox.2015.07.003
URN:NBN	urn:nbn:hr:105:524932
Publication	2015-09-01
Document URL	https://doi.org/10.1016/j.tox.2015.07.003
Type of resource	Text
Access conditions	Open access
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Created on	2024-03-28 08:59:45