prikaz prve stranice dokumenta Botulinum neurotoxin type A: actions beyond SNAP-25?
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Botulinum neurotoxin type A: actions beyond SNAP-25?
Toxicology, 335 (2015); 79-84. https://doi.org/10.1016/j.tox.2015.07.003
Matak, Ivica; Lacković, Zdravko

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Matak, I. i Lacković, Z. (2015). Botulinum neurotoxin type A: actions beyond SNAP-25?. Toxicology, 335., 79-84. doi: 10.1016/j.tox.2015.07.003

Matak, Ivica i Zdravko Lacković. "Botulinum neurotoxin type A: actions beyond SNAP-25?." Toxicology, vol. 335, 2015, str. 79-84. https://doi.org/10.1016/j.tox.2015.07.003

Matak, Ivica i Zdravko Lacković. "Botulinum neurotoxin type A: actions beyond SNAP-25?." Toxicology 335 (2015): 79-84. https://doi.org/10.1016/j.tox.2015.07.003

Matak, I. i Lacković, Z. (2015) 'Botulinum neurotoxin type A: actions beyond SNAP-25?', Toxicology, 335, str. 79-84. doi: 10.1016/j.tox.2015.07.003

Matak I, Lacković Z. Botulinum neurotoxin type A: actions beyond SNAP-25?. Toxicology [Internet]. 01.09.2015. [pristupljeno 29.11.2024.];335:79-84. doi: 10.1016/j.tox.2015.07.003

I. Matak i Z. Lacković, "Botulinum neurotoxin type A: actions beyond SNAP-25?", Toxicology, vol. 335, str. 79-84, Rujan 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:524932. [Citirano: 29.11.2024.]

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Podaci o radu
Naslov (engleski)Botulinum neurotoxin type A: actions beyond SNAP-25?
AutorIvica Matak
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Botulinum neurotoxin type A (BoNT/A), the most potent toxin known in nature which causes botulism, is a commonly used therapeutic protein. It prevents synaptic vesicle neuroexocytosis by proteolytic cleavage of synaptosomal-associated protein of 25 kDa (SNAP-25). It is widely believed that BoNT/A therapeutic or toxic actions are exclusively mediated by SNAP-25 cleavage. On the other hand, in vitro and in vivo findings suggest that several BoNT/A actions related to neuroexocytosis, cell cycle and apoptosis, neuritogenesis and gene expression are not necessarily mediated by this widely accepted mechanism of action. In present review we summarize the literature evidence which point to the existence of unknown BoNT/A molecular target(s) and modulation of unknown signaling pathways. The effects of BoNT/A apparently independent of SNAP-25 occur at similar doses/concentrations known to induce SNAP-25 cleavage and prevention of neurotransmitter release. Accordingly, these effects might be pharmacologically significant. Potentially the most interesting are observations of antimitotic and antitumor activity of BoNT/A. However, the exact mechanisms require further studies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaToxicology
Brojčani podacivol. 335, str. 79-84
p-ISSN0300-483X
DOIhttps://doi.org/10.1016/j.tox.2015.07.003
URN:NBNurn:nbn:hr:105:524932
Datum objave publikacije2015-09-01
URL dokumentahttps://doi.org/10.1016/j.tox.2015.07.003
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:59:45