Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome

Scientific paper - Original scientific paper

• Author: Mario Habek
• Author: Magdalena Krbot Skorić
• Author: Luka Crnošija
• Author: Tereza Gabelić
• Author: Barbara Barun
• Author: Ivan Adamec
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

BACKGROUND/AIMS:

There have been suggestions that interactions exist between the autonomic nervous system (ANS) and the immune system functions in multiple sclerosis (MS). We aimed to evaluate the ANS dysfunction, more specifically postural orthostatic tachycardia syndrome (POTS), as a possible predictor of conversion to MS in patients with clinically isolated syndrome (CIS). -----

METHODS:

In this observational, prospective, longitudinal study, 84 patients were enrolled (56 females, mean age 32.9 ± 8.9 years). Disease activity during a 6-month period was monitored (relapses and/or MRI disease activity indicated by new T2 or T1 enhancing lesions), and the following predictors analyzed: age, Expanded Disability Status Scale, MRI midbrain, pontine or medulla oblongata lesions, and POTS on the head up tilt test. -----

RESULTS:

POTS was identified in 8 (9.5%) patients. Of 84 patients, 62 (73.8%) completed the 6-month follow-up, and 28 (45.2%) patients converted to MS. Results of the multivariate regression analysis revealed age (10-year increase) and POTS as significant predictors of early conversion to MS (OR 2.34, 95% CI 1.15-4.78, p = 0.019 and OR 12.40, 95% CI 1.13-136.62, p = 0.040). The logistic model was statistically significant, χ2 (6) = 13.885, p = 0.031. -----

CONCLUSION:

POTS may be an indicator of a more active disease course in CIS patients and possibly be used as a prognostic factor.

• Keywords (english): Adult; Demyelinating Diseases/complications; Demyelinating Diseases/physiopathology; Disease Progression; Female; Humans; Longitudinal Studies; Male; Multiple Sclerosis/complications; Multiple Sclerosis/physiopathology; Postural Orthostatic Tachycardia Syndrome/complications; Prospective Studies; Young Adult
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: European Neurology
• Numbering: vol. 77, no. 5-6, pp. 253-257
• p-ISSN: 0014-3022
• DOI: https://doi.org/10.1159/000469707
• URN:NBN: urn:nbn:hr:105:756368
• Publication: 2017
• Document URL: http://doi.org/10.1159/000469707
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 09:18:32