prikaz prve stranice dokumenta Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
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Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
European Neurology, 77 (2017), 5-6; 253-257. https://doi.org/10.1159/000469707
Habek, Mario; Krbot Skorić, Magdalena; Crnošija, Luka; Gabelić, Tereza; Barun, Barbara; Adamec, Ivan

Citirajte ovaj rad

Habek, M., Krbot Skorić, M., Crnošija, L., Gabelić, T., Barun, B. i Adamec, I. (2017). Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome. European Neurology, 77. (5-6), 253-257. doi: 10.1159/000469707

Habek, Mario, et al. "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome." European Neurology, vol. 77, br. 5-6, 2017, str. 253-257. https://doi.org/10.1159/000469707

Habek, Mario, Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Barbara Barun i Ivan Adamec. "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome." European Neurology 77, br. 5-6 (2017): 253-257. https://doi.org/10.1159/000469707

Habek, M., et al. (2017) 'Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome', European Neurology, 77(5-6), str. 253-257. doi: 10.1159/000469707

Habek M, Krbot Skorić M, Crnošija L, Gabelić T, Barun B, Adamec I. Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome. European Neurology [Internet]. 2017. [pristupljeno 28.11.2024.];77(5-6):253-257. doi: 10.1159/000469707

M. Habek, M. Krbot Skorić, L. Crnošija, T. Gabelić, B. Barun i I. Adamec, "Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome", European Neurology, vol. 77, br. 5-6, str. 253-257, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:756368. [Citirano: 28.11.2024.]

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Naslov (engleski)Postural orthostatic tachycardia predicts early conversion to multiple sclerosis after clinically isolated syndrome
AutorMario Habek
AutorMagdalena Krbot Skorić
AutorLuka Crnošija
AutorTereza Gabelić
AutorBarbara Barun
AutorIvan Adamec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND/AIMS: There have been suggestions that interactions exist between the autonomic nervous system (ANS) and the immune system functions in multiple sclerosis (MS). We aimed to evaluate the ANS dysfunction, more specifically postural orthostatic tachycardia syndrome (POTS), as a possible predictor of conversion to MS in patients with clinically isolated syndrome (CIS). ----- METHODS: In this observational, prospective, longitudinal study, 84 patients were enrolled (56 females, mean age 32.9 ± 8.9 years). Disease activity during a 6-month period was monitored (relapses and/or MRI disease activity indicated by new T2 or T1 enhancing lesions), and the following predictors analyzed: age, Expanded Disability Status Scale, MRI midbrain, pontine or medulla oblongata lesions, and POTS on the head up tilt test. ----- RESULTS: POTS was identified in 8 (9.5%) patients. Of 84 patients, 62 (73.8%) completed the 6-month follow-up, and 28 (45.2%) patients converted to MS. Results of the multivariate regression analysis revealed age (10-year increase) and POTS as significant predictors of early conversion to MS (OR 2.34, 95% CI 1.15-4.78, p = 0.019 and OR 12.40, 95% CI 1.13-136.62, p = 0.040). The logistic model was statistically significant, χ2 (6) = 13.885, p = 0.031. ----- CONCLUSION: POTS may be an indicator of a more active disease course in CIS patients and possibly be used as a prognostic factor.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Neurology
Brojčani podacivol. 77, br. 5-6, str. 253-257
p-ISSN0014-3022
DOIhttps://doi.org/10.1159/000469707
URN:NBNurn:nbn:hr:105:756368
Datum objave publikacije2017
URL dokumentahttp://doi.org/10.1159/000469707
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:18:32