prikaz prve stranice dokumenta Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?
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Scientific paper - Original scientific paper
Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?
Frontiers in Cell and Developmental Biology, 7 (2019); https://doi.org/10.3389/fcell.2019.00027
Ilić, Katarina; Auer, Benedikt; Mlinac-Jerković, Kristina; Herrera-Molina, Rodrigo

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Ilić, K., Auer, B., Mlinac Jerković, K. & Herrera Molina, R. (2019). Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?. Frontiers in Cell and Developmental Biology, 7.. doi: 10.3389/fcell.2019.00027

Ilić, Katarina, et al. "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?." Frontiers in Cell and Developmental Biology, vol. 7, 2019. https://doi.org/10.3389/fcell.2019.00027

Ilić, Katarina, Benedikt Auer, Kristina Mlinac Jerković and Rodrigo Herrera Molina. "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?." Frontiers in Cell and Developmental Biology 7 (2019). https://doi.org/10.3389/fcell.2019.00027

Ilić, K., et al. (2019) 'Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?', Frontiers in Cell and Developmental Biology, 7. doi: 10.3389/fcell.2019.00027

Ilić K, Auer B, Mlinac Jerković K, Herrera Molina R. Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?. Frontiers in Cell and Developmental Biology [Internet]. 2019 March 07 [cited 2024 December 03];7. doi: 10.3389/fcell.2019.00027

K. Ilić, B. Auer, K. Mlinac Jerković and R. Herrera Molina, "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?", Frontiers in Cell and Developmental Biology, vol. 7, March 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:480995. [Accessed: 03 December 2024]

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Metadata
Title (english)Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?
AuthorKatarina Ilić
AuthorBenedikt Auer
AuthorKristina Mlinac-Jerković
AuthorRodrigo Herrera-Molina
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl phosphatidylinositol tail. Thy-1 displays a number of interesting properties such as fast lateral diffusion, which allows it to get in and out of membrane nanodomains with different lipid composition. Thy-1 displays a broad expression in different cell types and plays confirmed roles in cell development, adhesion and differentiation. Here, we explored the functions of Thy-1 in neuronal signaling, initiated by extracellular binding of aVb3 integrin, may strongly dependent on the lipid content of the cell membrane. Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides. Furthermore, we argue that Thy-1 positioning in nanodomains may be influenced by gangliosides. We propose that the traditional conception of Thy-1 localization in rafts should be reconsidered and evaluated in detail based on the potential diversity of neuronal nanodomains.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Cell and Developmental Biology
Numberingvol. 7
p-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2019.00027
URN:NBNurn:nbn:hr:105:480995
Publication2019-03-07
Document URLhttp://doi.org/10.3389/fcell.2019.00027
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:24:47