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Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?
Frontiers in Cell and Developmental Biology, 7 (2019); https://doi.org/10.3389/fcell.2019.00027
Ilić, Katarina; Auer, Benedikt; Mlinac-Jerković, Kristina; Herrera-Molina, Rodrigo

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Ilić, K., Auer, B., Mlinac Jerković, K. i Herrera Molina, R. (2019). Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?. Frontiers in Cell and Developmental Biology, 7.. doi: 10.3389/fcell.2019.00027

Ilić, Katarina, et al. "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?." Frontiers in Cell and Developmental Biology, vol. 7, 2019. https://doi.org/10.3389/fcell.2019.00027

Ilić, Katarina, Benedikt Auer, Kristina Mlinac Jerković i Rodrigo Herrera Molina. "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?." Frontiers in Cell and Developmental Biology 7 (2019). https://doi.org/10.3389/fcell.2019.00027

Ilić, K., et al. (2019) 'Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?', Frontiers in Cell and Developmental Biology, 7. doi: 10.3389/fcell.2019.00027

Ilić K, Auer B, Mlinac Jerković K, Herrera Molina R. Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?. Frontiers in Cell and Developmental Biology [Internet]. 07.03.2019. [pristupljeno 28.11.2024.];7. doi: 10.3389/fcell.2019.00027

K. Ilić, B. Auer, K. Mlinac Jerković i R. Herrera Molina, "Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?", Frontiers in Cell and Developmental Biology, vol. 7, Ožujak 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:480995. [Citirano: 28.11.2024.]

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Naslov (engleski)Neuronal signaling by Thy-1 in nanodomains with specific ganglioside composition: shall we open the door to a new complexity?
AutorKatarina Ilić
AutorBenedikt Auer
AutorKristina Mlinac-Jerković
AutorRodrigo Herrera-Molina
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl phosphatidylinositol tail. Thy-1 displays a number of interesting properties such as fast lateral diffusion, which allows it to get in and out of membrane nanodomains with different lipid composition. Thy-1 displays a broad expression in different cell types and plays confirmed roles in cell development, adhesion and differentiation. Here, we explored the functions of Thy-1 in neuronal signaling, initiated by extracellular binding of aVb3 integrin, may strongly dependent on the lipid content of the cell membrane. Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides. Furthermore, we argue that Thy-1 positioning in nanodomains may be influenced by gangliosides. We propose that the traditional conception of Thy-1 localization in rafts should be reconsidered and evaluated in detail based on the potential diversity of neuronal nanodomains.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Cell and Developmental Biology
Brojčani podacivol. 7
p-ISSN2296-634X
DOIhttps://doi.org/10.3389/fcell.2019.00027
URN:NBNurn:nbn:hr:105:480995
Datum objave publikacije2019-03-07
URL dokumentahttp://doi.org/10.3389/fcell.2019.00027
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:24:47