prikaz prve stranice dokumenta Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes
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Scientific paper - Original scientific paper
Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes
Collegium Antropologicum, 32 (2008), 1; 119-123. urn:nbn:hr:105:597296
Roša, Jagoda; Baraba, Anja; Bučević, Petra; Đorđijevski, Darija; Antolković, Ivan; Roša, Josip

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Roša, J., Baraba, A., Bučević, P., Đorđijevski, D., Antolković, I. & Roša, J. (2008). Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes. Collegium Antropologicum, 32. (1), 119-123. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:597296

Roša, Jagoda, et al. "Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes." Collegium Antropologicum, vol. 32, no. 1, 2008, pp. 119-123. https://urn.nsk.hr/urn:nbn:hr:105:597296

Roša, Jagoda, Anja Baraba, Petra Bučević, Darija Đorđijevski, Ivan Antolković and Josip Roša. "Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes." Collegium Antropologicum 32, no. 1 (2008): 119-123. https://urn.nsk.hr/urn:nbn:hr:105:597296

Roša, J., et al. (2008) 'Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes', Collegium Antropologicum, 32(1), pp. 119-123. Available at: https://urn.nsk.hr/urn:nbn:hr:105:597296 (Accessed 01 October 2024)

Roša J, Baraba A, Bučević P, Đorđijevski D, Antolković I, Roša J. Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes. Collegium Antropologicum [Internet]. 2008 March [cited 2024 October 01];32(1):119-123. Available at: https://urn.nsk.hr/urn:nbn:hr:105:597296

J. Roša, A. Baraba, P. Bučević, D. Đorđijevski, I. Antolković and J. Roša, "Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes", Collegium Antropologicum, vol. 32, no. 1, pp. 119-123, March 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:597296. [Accessed: 01 October 2024]

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Metadata
Title (english)Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes
AuthorJagoda Roša
AuthorAnja Baraba
AuthorPetra Bučević
AuthorDarija Đorđijevski
AuthorIvan Antolković
AuthorJosip Roša
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Increased dietary fat intake generally, and saturated fat specifically, will lead to impairment of insulin action and to development of metabolic syndrome. The aim of this study was to find out changing of hepatic glucose output in dependence of high monounsaturated and high polyunsaturated fat diet and possible direct action of insulin in hepatocytes. Hepatocytes were isolated by a collagenase perfusion technique and cultured for 24 h in M 199 serum-free medium. The glucose production in hepatocytes isolated from rats on high polyunsaturated fat diet, as well as those isolated from rats on high monounsaturated fat diet was significantly higher than in standard controls. Insulin significantly decreased glucose production but only in hepatocytes obtained from rats on high monounsaturated fat diet. On the other side energy expenditure was significantly higher in rats on high monounsaturated fat diet and significantly lower in rats on high polyunsaturated fat diet comparable with animals on standard diet. Monounsaturated fat in Mediterranean diet could have beneficial effect on the development of the metabolic syndrome by increasing insulin sensitivity and energy expenditure.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 1, pp. 119-123
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:597296
Publication2008-03
Document URLhttps://hrcak.srce.hr/22824
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:45:55