Klinički i imunohistokemijski čimbenici koji utječu na ishod bolesti u bolesnika koji boluju od klasičnog tipa Hodgkinovog limfoma

master's thesis

• Title (english): Clinical and immunohistochemical characteristics that affect the outcome of patients with the classical type of Hodgkin lymphoma
• Author: Ksenija Prodan
• Mentor: Ivana Ilić (mentor)
• Committee member: Dubravko Jalšovec (predsjednik povjerenstva)
• Committee member: Slavko Gašparov (član povjerenstva)
• Committee member: Sven Seiwerth (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Hodgkinov limfom je zloćudna novotvorina koja se dijeli na dva zasebna entiteta - nodularnu limfocitnu predominaciju i klasični Hodgkinov limfom. Klasični Hodgkinov limfom (kHL) je bolest sa izrazito visokim postotkom povoljnih ishoda. Svrha određivanja prognostičkih čimbenika je pronalazak bolesnika koji imaju veću mogućnost nepovoljnog ishoda nakon prve linije terapije. Cilj ovog rada je potvrditi utjecaj nepovoljnih prognostičkih čimbenika u trenutku postavljanja dijagnoze na ishod liječenja bolesnika koji boluju od klasičnog tipa Hodgkinovog limfoma. Analizirani su podaci 118 bolesnika liječenih u KBC-u Zagreb od siječnja 2011. do travnja 2015. godine. Analizirani čimbenici su klinički- dob, spol, klinički stadij, odgovor na liječenje; laboratorijski- apsolutni broj leukocita iz periferne krvi u vrijeme dijagnoze, apsolutni broj monocita iz periferne krvi u vrijeme dijagnoze te patohistološki- podtip kHL-a, ekspresija CD20 i CD15 biljega na tumorskim stanicama. Nije nađen statistički značajan utjecaj navedenih čimbenika na ishod bolesti. Zaključno, iako čimbenici analizirani u ovom radu nisu pokazali povezanost s utjecajem na ishod bolesti, moguć utjecaj drugih prognostičkih čimbenika pomogao bi u izdvajanju bolesnika koje je potrebno liječiti agresivnijom terapijom te posljedično pridonio njihovu izlječenju.

Abstract (english)

Hodgkin lymphoma is a lymphoid neoplasm that can be divided into two entities: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Classical Hodgkin lymphoma is a malignancy with a high percentage of
favourable outcomes. The purpose of determining prognostic factors is identifying patients with a higher likelihood of unfavorable outcome after first-line therapy. The aim of this study is confirming the affect of unfavourable prognostic factors at the time of diagnosis on the outcome of patients with the classical type of Hodgkin lymphoma. We studied 118 patients treated at the Clinical Hospital Centre Zagreb from January 2011 to April 2015. The analyzed factors included clinical prognostic factors- age, sex, clinical stage, response to treatment; laboratory factors- peripheral blood absolute leukocyte count at the time of diagnosis, peripheral blood absolute monocyte count at the time of diagnosis, and pathohistological factors- cHL subtype, CD20 and CD15 tumor cell expression. The aforementioned prognostic factors did not show their independent statistical significance on the outcome. In conclusion, although the prognostic factors analyzed in this study did not confirm the connection to the outcome, the possible affect of other prognostic factors could help differentiating the patients who may benefit from more intensive therapy.

• Keywords: Hodgkinov limfom; prognostički čimbenici; ishod
• Keywords (english): Hodgkin lymphoma; prognostic factors; outcome
• Language: croatian
• URN:NBN: urn:nbn:hr:105:751565
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-12-01 11:07:48