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Periprotetička infekcija nakon ugradnje totalne endoproteze kuka
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Ivana Vukadin Totalna endoproteza kuka je čest postupak u ortopediji kojim se odstranjuje oštećena
kost i hrskavica koja se zamjenjuje protetskim komponentama. Totalna endoproteza kuka koju
obavlja iskusni kirurški tim daje vrlo učinkovite rezultate, pružajući olakšanje boli,
funkcionalnu obnovu i poboljšanu kvalitetu života no treba biti svjestan mogućih komplikacija
postupka. Jedna od čestih komplikacija nakon ugradnje totalne endoproteze kuka je infekcija.
Za uspješno liječenje...
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Peritonitis u bolensik an peritonejskoj dijalizi
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Anamarija Štajduhar Unatoč brojnim prednostima koje nudi PD, postotak bolesnika u završnoj fazi bubrežne bolesti koji koristi ovu metodu opada, prvenstveno zbog najozbiljnije komplikacije ovog oblika terapije, a to je peritonitis. Cilj je ovog rada bilo prikazati demografske osobine pacijenata s peritonitisom povezanim s PD, rizične čimbenike za razvoj bolesti, terapiju i ishod. Ovo retrospektivno istraživanje provedeno je na Zavodu za nefrologiju i dijalizu u KBC-u Sestre milosrdnice u Zagrebu....
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Perkutana implantacija aortne valvule u usporedbi s kirurškom zamjenom valvule u bolesnika niskog rizika
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Katarina Matić Aortalna stenoza (AS) najčešća je bolest srčanih zalistaka, a prevalencija joj svake godine raste kao posljedica starenja stanovništva. Zamjena nativnog aortalnog zaliska definitivna je metoda liječenja teške simptomatske aortalne stenoze. Dugi niz godina kirurška zamjena aortalnog zaliska (SAVR) bila je jedina dostupna metoda liječenja za pacijente s teškom aortalnom stenozom. Razvoj minimalno invazivne kirurgije i perkutane implantacije aortalne valvule započeo je revoluciju u...
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Personalizirana metabolomika u funkciji procjene predispozicije, prepoznavanju rizika i prevenciji debljine u djece
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Lucia Mrđen Prekomjerna tjelesna težina i pretilost ogroman su problem zdravstvenog sustava. Više od milijardu ljudi na svijetu ima prekomjernu tjelesnu težinu, a tristo milijuna ljudi je pretilo. Povezanost debljine s brojnim kroničnim bolestima i narušenom kvalitetom života sve više ističe važnost prevencije i rane dijagnostike prekomjerne tjelesne težine, a samim time i povezanih komplikacija. Metabolomika je jedna od grana „multi-omics“ pristupa, koja omogućava personalizirani pristup...
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Pharmacogenetics in the treatment of schizophrenia - current status
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Joseph Clyde Wycoco Schizophrenia is a widespread mental disease that affects about 1% of the world population. Because of the complex heritability of the disease as well as limited knowledge of the precise interconnected biochemical and genetic mechanisms underlying schizophrenia, there is wide variability in terms of antipsychotic drug efficacy, treatment effects, presence and severity of side-effects. With the completion of the mapping of the human genome, genome-wide association studies (GWAS) bring...
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Pharmacological therapies for acute cardiogenic shock
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Marija Radić Cardiogenic shock (CS) is a life threatening condition, a state of end-organ hypoperfusion, caused by cardiac failure leading to low cardiac output and inability of cardiovascular system to provide adequate flow of oxygen-rich blood to body-extremities and vital organs. This is a clinical syndrome characterized by a systemic hypotension <90 mmHg, and signs of tissue hypoperfusion,
usually as a sequela of an acute myocardial infarction. Cardiogenic shock can also arise from nonischemic...
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Phase IV clinical trials
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Armin Hadrys A phase IV clinical trial is an important step in the surveillance of a new drug after its approval for release on the market. It is an essential part of post-marketing research that focuses on realworld effectiveness and pharmacovigilance, thus not only continuing previous studies, but complementing them. Phase IV clinical trials differ significantly in their study design, their requirements, and their scientific demand from previous study phases. Phases I to III mainly examine the safety...
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Physician liability - comparison between the Croatian Criminal Code and criminal code in Slovenia
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Štefan Smogavc Physician liability laws are basic pillars of every civilized nation with organized health care. I will compare physician liability in criminal code between Slovenia and Croatia. Although countries use to have the same history and were under the same government, nowadays probably there are some differences in their new legal systems after both countries declared their independace around the same time 1991. Medicine has many different types of laws on different levels and legislative...
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Placebo učinak u liječenju bolesti
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Bogdan Bošnjak Placebo i placebo učinak oduvijek su prisutni u povijesti medicine, no kroz stoljeća nisu dobivali uvijek istu pažnju. Spomen placeba nalazimo u svih poznatih civilizacija još od rane antike. Dugo vremena između umjetnosti i znanosti, koncept placeba je u mnogim slučajevima povezan s velikim brojem mitova i pogrešnih shvaćanja, od kojih je najpopularniji onaj u kojem je placebo koristan samo u psihjatrijskim poremećajima, te da je to “onaj lijek” koji koristi liječnik kada nema...
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Placebo, nocebo, and care effect
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Mathilde Alice Krähenbühl Placebo, nocebo and care effect by Mathilde Alice Krähenbühl. Placebo, nocebo and care responses are an interesting challenge of eastern medicine. From their definitions and the problems arising through them, to their usage in randomized controlled trials, they fascinate and confuse. However, when demystified and properly defined, they represent a very good model for the understanding of the role of context within treatment and can be used to the advantage of modern science. The placebo,...
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Plan otpusta palijativnog pacijenta s kirurškog odjela
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Hrvojka Stipetić Jedan od indikatora kvalitete je plan otpusta palijativnog pacijenta iz zdravstvene ustanove. Zbog učestalih promjena u društvu i zdravstvenom sustavu sve više se pažnje posvećuje kvalitetnom planu otpusta, naročito palijativnih pacijenata. Pravovremenim prepoznavanjem pacijenta koji ima potrebu za palijativnom skrbi i upisom u registar palijativne skrbi pridajemo važnost kvaliteti života pacijenta. Palijativni timovi u zdravstvenim ustanovama procjenjuju stanje pacijenta i sukladno...
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Platelet aggregation defects in women with endometriosis
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Mohammad Omar Rahimy Major progress has been seen in the past few decades in the management of gynecological conditions and obstetric care in women with bleeding disorders (BDs). However, there remain many ambiguous issues within the field. A sequence of observational studies was conducted to address these issues with a goal to improve patient care. In the recent findings showing that platelets play important roles in the development of endometriosis. Hence, this review was undertaken to see if there was a...
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