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The role of the FaS/FasL apoptotic pathway on osteoclastogenesis in the mouse model of controlled tibial fractures
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Nina Lukač The Fas/FasL apoptotic system serves as a regulator of the immune system, but also has an influence on osteoclast survival and differentiation. The model of internally fixated controlled tibial fractures was used to evaluate its role on osteoclastogenesis in formation of new bone, as fracture healing serves as a model for embryonic skeletal development. The aim of this study was to evaluate the role of the apoptotic system on osteoclastogenesis in vivo, by evaluating the osteoclastogenic...
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The usage of antibiotics in bone surgery
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Patrick Julien Bernard Tschechne The discovery of antibiotics has drastically changed modern medicine and everyday human life. Even though extraordinary discoveries have been made perioperative infections are still commonly encountered in clinical practice. Deep infections such as septic arthritis, osteomyelitis and periprosthetic joint infections pose great difficulties to practising surgeons and increase the financial burden for health care systems across the globe. Multiple antibiotic regimens are commonly used where...
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The use of alternative vascular access in emergency care
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Máté Huba Huszár A variety of alternative emergency vascular access solutions have been tested and described in the literature. In cases of difficult intravenous access (DIVA) in emergency settings, intraosseous access (IO) has consistently been suggested by professional organisations as the most suitable alternative to peripheral venous catheters (PVC) due to its proven superiority. IO is the quickest and safest option when immediate intravenous access cannot be established.
This thesis, as a descriptive...
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The use of botulinum toxin in medicine
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Lara Kralj Neurotoxin made by a bacterium called Clostridium botulinum is an important medical
substance. It is so versatile, that it can be used as a lethal weapon and in modern medicine is
even gaining its popularity in the aesthetic procedures. Although it was first recognized as
early as 1793 in Germany, it was not until 1989 that surgeons found its beneficial usages in
medicine. The so called »miracle poison« exists in eight different exotoxins
(A,B,C1,C2,D,E,F,G) – the most potent being...
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The use of fecal microbiota transplantation in gastrointestinal diseases
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Jannat Monosi Ali Fecal microbiota transplantation (FMT) is a treatment modality that involves the process of transplanting fecal matter obtained from a selected donor to a recipient in order to restore the microbial homeostasis in the intestine. Although the utilization of fecal matter to treat diseased individuals can be traced to the 4th century, China, it was not until the end of the 20th century that Western countries began to study the potential role of FMT. Since then, there has been a growing interest...
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The use of lasers in dermatology
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Kristina Žužul This graduate thesis explains the basic laser principles and provides an overview of
indications for laser treatment in dermatology. The term laser is an acronym for light
amplification by the stimulated emission of radiation. Since the development of first laser by
Maiman and the introduction of theory of selective photothermolysis in 1980 by Anderson
and Parish, it gained widespread acceptance in dermatology and is now used for the treatment
of numerous cutaneous conditions including...
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The use of tourniquet in limb surgery
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Martial Matthias Coudert The tourniquet is routinely used in daily practice for upper and lower limb orthopedic surgery, in order to obtain a bloodless surgical field and thus, to allow a better visualization for the surgeon. Tourniquet use is associated to several local and systemic complications which can be disabling or even lethal, including pulmonary embolism, reperfusion injury, and permanent neurological damage. Several conditions can be considered as contraindications for the use of tourniquet, even though...
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Thyroid cancer – treatment options
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Roman Ritter Thyroid cancer is rapidly increasing in incidence, yet the mortality rate remains relatively constant. Given its’ favorable prognosis and great success in treatment of the most common types, it is currently debated, whether the incidence rise should change the way the screening is performed and affect the established treatment guidelines. In this literature review four of the most prominent thyroid gland cancers and their management options are presented; papillary, follicular, medullary...
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Tibialis posterior dysfunction
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Maja Đinkić Posterior tibial tendon stabilizes the medial arch of the foot and has a crucial role
during gait. Posterior tibial tendon dysfunction is a clinical condition characterized by
hindfoot valgus, collapsed longitudinal arch, and abduction and supination of the
forefoot. Over the past twenty years, the incidence of posterior tibial tendon
dysfunction has been rising, most frequently occurring in middle-aged women. It is a
common and treatable cause of adult acquired flatfoot. Posterior...
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Tihi moždani udar
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Ana Marija Jurić Tihi moždani udar je čest nalaz na modernim radiološkim pretragama mozga. Čak do 30% osoba bez povijesti moždanog udara na slikovnim pretragama rađenim u sklopu brojnih epidemioloških studija ima znakove moždanog udara. Termin „tihi“ podrazumijeva nedostatak jasne kliničke slike uz slučajni pronalazak ishemijskih lezija metodama magnetske rezonancije ili CT-a. Ipak, danas je sve jasnije da ova vrsta moždanog udara uopće nije „tiha“, već u velikom broju slučajeva...
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Tijek i ishod blizanačkih trudnoća na Klinici za ginekologiju i porodništvo Kliničke bolnice "Sv. Duh"
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Mia Buršić Tijek i ishod blizanačkih trudnoća razlikuje se od jednoplodnih trudnoća po prosječnom trajanju trudnoće i učestalosti nekih komplikacija trudnoće, načinu i komplikacijama porođaja te učestalosti lošijih neonatalnih ishoda. Osim toga, blizanačke trudnoće izložene su i određenim specifičnim rizicima, poput razvoja međublizanačkog transfuzijskog sindroma. Ovo retrospektivno istraživanje provedeno je u KB „Sveti Duh“ u razdoblju od 1. siječnja 2014. do 31. prosinca 2016....
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Tijek i ishod trudnoća kompliciranih mijastenijom gravis
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Ozana Miličević Mijastenija gravis (MG) je stečena autoimuna bolest koja nastaje kao posljedica
stvaranja protutijela na acetilkolinske receptore (AChR) završne motorne ploče čime
se narušava prijenos signala neuromuskularne spojnice. Usprkos nepoznavanju
točnog uzroka smatra se da je bolest multifaktorijalne etiologije. Dobna raspodjela MG
koja svoj vrh doseže u reproduktivnoj dobi žene zahtjeva pojačanu prekoncepcijsku,
antenatalnu i postpartalnu skrb. Prema raširenosti simptoma MG...
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