prikaz prve stranice dokumenta Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
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Scientific paper - Original scientific paper
Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
Antioxidants, 13 (2024), 3; 339. https://doi.org/10.3390/antiox13030339
Klobučar, Iva; Hofmann, Lidija; Habisch, Hansjörg; Lechleitner, Margarete; Klobučar, Lucija; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Madl, Tobias; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Hofmann, L., Habisch, H., Lechleitner, M., Klobučar, L., Trbušić, M. ... Degoricija, V. (2024). Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome. Antioxidants, 13. (3). doi: 10.3390/antiox13030339

Klobučar, Iva, et al. "Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome." Antioxidants, vol. 13, no. 3, 2024. https://doi.org/10.3390/antiox13030339

Klobučar, Iva, Lidija Hofmann, Hansjörg Habisch, Margarete Lechleitner, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, et al. "Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome." Antioxidants 13, no. 3 (2024). https://doi.org/10.3390/antiox13030339

Klobučar, I., et al. (2024) 'Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome', Antioxidants, 13(3). doi: 10.3390/antiox13030339

Klobučar I, Hofmann L, Habisch H, Lechleitner M, Klobučar L, Trbušić M, and sur.. Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome. Antioxidants [Internet]. 2024 March 11 [cited 2024 December 24];13(3). doi: 10.3390/antiox13030339

I. Klobučar, et al., "Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome", Antioxidants, vol. 13, no. 3, March 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:003833. [Accessed: 24 December 2024]

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Metadata
Title (english)Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
AuthorIva Klobučar
AuthorLidija Hofmann
AuthorHansjörg Habisch
AuthorMargarete Lechleitner
AuthorLucija Klobučar
AuthorMatias Trbušić
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorTobias Madl
AuthorSaša Frank
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients with metabolic syndrome (MS). The serum levels of AOPPs were significantly positively correlated with the serum levels of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL); however, they were significantly negatively correlated with high-density lipoprotein (HDL). These lipoproteins (and their subclasses) differed markedly regarding the direction of correlations between their lipid contents and AOPPs. The strength of the correlations and the relative contributions of the subclasses to the correlations were different in the HVs and patients with MS. As revealed by orthogonal partial least squares discriminant analyses, the serum levels of IDL were strong determinants of AOPPs in the HVs, whereas the serum levels of VLDL and the lipid content of LDL were strong determinants in both groups. We conclude that IDL, VLDL, and LDL facilitate, whereas HDL diminishes the bioavailability of serum AOPPs. The presence of MS and the lipid contents of the subclasses affect the relationship between lipoproteins and AOPPs.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntioxidants
Numberingvol. 13, no. 3, 339
e-ISSN2076-3921
DOIhttps://doi.org/10.3390/antiox13030339
URN:NBNurn:nbn:hr:105:003833
Publication2024-03-11
Document URLhttps://www.mdpi.com/2076-3921/13/3/339
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-10-22 08:31:25