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Scientific paper - Original scientific paper
The Value of Local Therapies in Advanced Adrenocortical Carcinoma
Cancers, 16 (2024), 4; 706. https://doi.org/10.3390/cancers16040706
Kimpel, Otilia; Altieri, Barbara; Laganà, Marta; Vogl, Thomas J.; Adwan, Hamzah; Dušek, Tina; Basile, Vittoria; Pittaway, James; Dischinger, Ulrich; Quinkler, Marcus; Kroiss, Matthias; Puglisi, Soraya; Cosentini, Deborah; Kickuth, Ralph; Kaštelan, Darko; Fassnacht, Martin More authors...

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Kimpel, O., Altieri, B., Laganà, M., Vogl, T. J., Adwan, H., Dušek, T. ... Fassnacht, M. (2024). The Value of Local Therapies in Advanced Adrenocortical Carcinoma. Cancers, 16. (4). doi: 10.3390/cancers16040706

Kimpel, Otilia, et al. "The Value of Local Therapies in Advanced Adrenocortical Carcinoma." Cancers, vol. 16, no. 4, 2024. https://doi.org/10.3390/cancers16040706

Kimpel, Otilia, Barbara Altieri, Marta Laganà, Thomas J. Vogl, Hamzah Adwan, Tina Dušek, Vittoria Basile, et al. "The Value of Local Therapies in Advanced Adrenocortical Carcinoma." Cancers 16, no. 4 (2024). https://doi.org/10.3390/cancers16040706

Kimpel, O., et al. (2024) 'The Value of Local Therapies in Advanced Adrenocortical Carcinoma', Cancers, 16(4). doi: 10.3390/cancers16040706

Kimpel O, Altieri B, Laganà M, Vogl TJ, Adwan H, Dušek T, and sur.. The Value of Local Therapies in Advanced Adrenocortical Carcinoma. Cancers [Internet]. 2024 February 07 [cited 2024 December 23];16(4). doi: 10.3390/cancers16040706

O. Kimpel, et al., "The Value of Local Therapies in Advanced Adrenocortical Carcinoma", Cancers, vol. 16, no. 4, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:909488. [Accessed: 23 December 2024]

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Metadata
Title (english)The Value of Local Therapies in Advanced Adrenocortical Carcinoma
AuthorOtilia Kimpel
AuthorBarbara Altieri
AuthorMarta Laganà
AuthorThomas J. Vogl
AuthorHamzah Adwan
AuthorTina Dušek
AuthorVittoria Basile
AuthorJames Pittaway
AuthorUlrich Dischinger
AuthorMarcus Quinkler
AuthorMatthias Kroiss
AuthorSoraya Puglisi
AuthorDeborah Cosentini
AuthorRalph Kickuth
AuthorDarko Kaštelan
AuthorMartin Fassnacht
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
International guidelines recommend local therapies (LTs) such as local thermal ablation (LTA; radiofrequency, microwave, cryoablation), transarterial (chemo)embolisation (TA(C)E), and transarterial radioembolisation (TARE) as therapeutic options for advanced adrenocortical carcinoma (ACC). However, the evidence for these recommendations is scarce. We retrospectively analysed patients receiving LTs for advanced ACC. Time to progression of the treated lesion (tTTP) was the primary endpoint. The secondary endpoints were best objective response, overall progression-free survival, overall survival, adverse events, and the establishment of predictive factors by multivariate Cox analyses. A total of 132 tumoural lesions in 66 patients were treated with LTA (n = 84), TA(C)E (n = 40), and TARE (n = 8). Complete response was achieved in 27 lesions (20.5%; all of them achieved by LTA), partial response in 27 (20.5%), and stable disease in 38 (28.8%). For the LTA group, the median tTTP was not reached, whereas it was reached 8.3 months after TA(C)E and 8.2 months after TARE (p < 0.001). The median time interval from primary diagnosis to LT was >47 months. Fewer than four prior therapies and mitotane plasma levels of >14 mg/L positively influenced the tTTP. In summary, this is one of the largest studies on LTs in advanced ACC, and it demonstrates a very high local disease control rate. Thus, it clearly supports the guideline recommendations for LTs in these patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCancers
Numberingvol. 16, no. 4, 706
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers16040706
URN:NBNurn:nbn:hr:105:909488
Publication2024-02-07
Document URLhttps://www.mdpi.com/2072-6694/16/4/706
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-13 14:39:29