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The Value of Local Therapies in Advanced Adrenocortical Carcinoma
Cancers, 16 (2024), 4; 706. https://doi.org/10.3390/cancers16040706
Kimpel, Otilia; Altieri, Barbara; Laganà, Marta; Vogl, Thomas J.; Adwan, Hamzah; Dušek, Tina; Basile, Vittoria; Pittaway, James; Dischinger, Ulrich; Quinkler, Marcus; Kroiss, Matthias; Puglisi, Soraya; Cosentini, Deborah; Kickuth, Ralph; Kaštelan, Darko; Fassnacht, Martin Više autora...

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Kimpel, O., Altieri, B., Laganà, M., Vogl, T. J., Adwan, H., Dušek, T. ... Fassnacht, M. (2024). The Value of Local Therapies in Advanced Adrenocortical Carcinoma. Cancers, 16. (4). doi: 10.3390/cancers16040706

Kimpel, Otilia, et al. "The Value of Local Therapies in Advanced Adrenocortical Carcinoma." Cancers, vol. 16, br. 4, 2024. https://doi.org/10.3390/cancers16040706

Kimpel, Otilia, Barbara Altieri, Marta Laganà, Thomas J. Vogl, Hamzah Adwan, Tina Dušek, Vittoria Basile, et al. "The Value of Local Therapies in Advanced Adrenocortical Carcinoma." Cancers 16, br. 4 (2024). https://doi.org/10.3390/cancers16040706

Kimpel, O., et al. (2024) 'The Value of Local Therapies in Advanced Adrenocortical Carcinoma', Cancers, 16(4). doi: 10.3390/cancers16040706

Kimpel O, Altieri B, Laganà M, Vogl TJ, Adwan H, Dušek T, i sur.. The Value of Local Therapies in Advanced Adrenocortical Carcinoma. Cancers [Internet]. 07.02.2024. [pristupljeno 19.12.2024.];16(4). doi: 10.3390/cancers16040706

O. Kimpel, et al., "The Value of Local Therapies in Advanced Adrenocortical Carcinoma", Cancers, vol. 16, br. 4, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:909488. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:909488
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Naslov (engleski)The Value of Local Therapies in Advanced Adrenocortical Carcinoma
AutorOtilia Kimpel
AutorBarbara Altieri
AutorMarta Laganà
AutorThomas J. Vogl
AutorHamzah Adwan
AutorTina Dušek
AutorVittoria Basile
AutorJames Pittaway
AutorUlrich Dischinger
AutorMarcus Quinkler
AutorMatthias Kroiss
AutorSoraya Puglisi
AutorDeborah Cosentini
AutorRalph Kickuth
AutorDarko Kaštelan
AutorMartin Fassnacht
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
International guidelines recommend local therapies (LTs) such as local thermal ablation (LTA; radiofrequency, microwave, cryoablation), transarterial (chemo)embolisation (TA(C)E), and transarterial radioembolisation (TARE) as therapeutic options for advanced adrenocortical carcinoma (ACC). However, the evidence for these recommendations is scarce. We retrospectively analysed patients receiving LTs for advanced ACC. Time to progression of the treated lesion (tTTP) was the primary endpoint. The secondary endpoints were best objective response, overall progression-free survival, overall survival, adverse events, and the establishment of predictive factors by multivariate Cox analyses. A total of 132 tumoural lesions in 66 patients were treated with LTA (n = 84), TA(C)E (n = 40), and TARE (n = 8). Complete response was achieved in 27 lesions (20.5%; all of them achieved by LTA), partial response in 27 (20.5%), and stable disease in 38 (28.8%). For the LTA group, the median tTTP was not reached, whereas it was reached 8.3 months after TA(C)E and 8.2 months after TARE (p < 0.001). The median time interval from primary diagnosis to LT was >47 months. Fewer than four prior therapies and mitotane plasma levels of >14 mg/L positively influenced the tTTP. In summary, this is one of the largest studies on LTs in advanced ACC, and it demonstrates a very high local disease control rate. Thus, it clearly supports the guideline recommendations for LTs in these patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 16, br. 4, 706
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers16040706
URN:NBNurn:nbn:hr:105:909488
Datum objave publikacije2024-02-07
URL dokumentahttps://www.mdpi.com/2072-6694/16/4/706
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-13 14:39:29