prikaz prve stranice dokumenta No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
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Scientific paper - Original scientific paper
No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
Nutrients, 16 (2024), 17; 3018. https://doi.org/10.3390/nu16173018
Li, Dandan; Jovanovski, Elena; Zurbau, Andreea; Sievenpiper, John; Miličić, Davor; El-Sohemy, Ahmed; Vuksan, Vladimir

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Li, D., Jovanovski, E., Zurbau, A., Sievenpiper, J., Miličić, D., El Sohemy, A. & Vuksan, V. (2024). No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial. Nutrients, 16. (17). doi: 10.3390/nu16173018

Li, Dandan, et al. "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial." Nutrients, vol. 16, no. 17, 2024. https://doi.org/10.3390/nu16173018

Li, Dandan, Elena Jovanovski, Andreea Zurbau, John Sievenpiper, Davor Miličić, Ahmed El Sohemy and Vladimir Vuksan. "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial." Nutrients 16, no. 17 (2024). https://doi.org/10.3390/nu16173018

Li, D., et al. (2024) 'No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial', Nutrients, 16(17). doi: 10.3390/nu16173018

Li D, Jovanovski E, Zurbau A, Sievenpiper J, Miličić D, El Sohemy A, and sur.. No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial. Nutrients [Internet]. 2024 September 06 [cited 2025 April 04];16(17). doi: 10.3390/nu16173018

D. Li, et al., "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial", Nutrients, vol. 16, no. 17, September 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:208378. [Accessed: 04 April 2025]

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Title (english)No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
AuthorDandan Li
AuthorElena Jovanovski
AuthorAndreea Zurbau
AuthorJohn Sievenpiper
AuthorDavor Miličić
AuthorAhmed El-Sohemy
AuthorVladimir Vuksan
MBZ: 53962
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Dietary inorganic nitrate lowers blood pressure (BP) in healthy individuals through improved nitric oxide (NO) bioavailability. However, there is limited evidence examining the long-term effects of dietary nitrate for managing hypertension. We aimed to determine whether the sustained intake of dietary nitrate improved BP and cardiovascular disease (CVD) risk factors in individuals with early-stage hypertension. The Dietary Nitrate (NO3) on BP and CVD Risk Factors (DINO3) Trial was a multi-center, double-blinded, parallel, randomized, controlled trial in participants with elevated BP. Participants were supplemented with high-nitrate (HN) (~400 mg nitrate) or low-nitrate (LN) vegetable powder (~50 mg nitrate) on top of their usual diets for 16 weeks. The primary outcome was office systolic BP at 16 weeks. The secondary outcomes were 24 h ambulatory BP, central BP, heart-rate-corrected augmentation index (AIx75), carotid–femoral pulse wave velocity (cf-PWV), lipids, and high-sensitivity C-reactive protein (hs-CRP). Sixty-six participants were randomized at baseline (39M:27F, age: 51.5 ± 10.8 years, BMI:27.9 ± 3.2 kg/m2). In an intention-to-treat analysis, no differences were observed between HN and LN groups in terms of office systolic BP at 16 weeks (3.91 ± 3.52 mmHg, p = 0.27) or secondary outcomes. In this exploratory study, sustained HN vegetable supplementation did not exhibit more favorable vascular effects than LN vegetable supplementation in individuals with elevated BP.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNutrients
Numberingvol. 16, no. 17, 3018
e-ISSN2072-6643
DOIhttps://doi.org/10.3390/nu16173018
URN:NBNurn:nbn:hr:105:208378
Publication2024-09-06
Document URLhttps://www.mdpi.com/2072-6643/16/17/3018
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-20 09:19:39