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No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
Nutrients, 16 (2024), 17; 3018. https://doi.org/10.3390/nu16173018
Li, Dandan; Jovanovski, Elena; Zurbau, Andreea; Sievenpiper, John; Miličić, Davor; El-Sohemy, Ahmed; Vuksan, Vladimir

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Li, D., Jovanovski, E., Zurbau, A., Sievenpiper, J., Miličić, D., El Sohemy, A. i Vuksan, V. (2024). No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial. Nutrients, 16. (17). doi: 10.3390/nu16173018

Li, Dandan, et al. "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial." Nutrients, vol. 16, br. 17, 2024. https://doi.org/10.3390/nu16173018

Li, Dandan, Elena Jovanovski, Andreea Zurbau, John Sievenpiper, Davor Miličić, Ahmed El Sohemy i Vladimir Vuksan. "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial." Nutrients 16, br. 17 (2024). https://doi.org/10.3390/nu16173018

Li, D., et al. (2024) 'No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial', Nutrients, 16(17). doi: 10.3390/nu16173018

Li D, Jovanovski E, Zurbau A, Sievenpiper J, Miličić D, El Sohemy A, i sur.. No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial. Nutrients [Internet]. 06.09.2024. [pristupljeno 08.04.2025.];16(17). doi: 10.3390/nu16173018

D. Li, et al., "No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial", Nutrients, vol. 16, br. 17, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:208378. [Citirano: 08.04.2025.]

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Naslov (engleski)No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 Weeks in Individuals with Early-Stage Hypertension: An Exploratory, Double-Blinded, Randomized, Controlled Trial
AutorDandan Li
AutorElena Jovanovski
AutorAndreea Zurbau
AutorJohn Sievenpiper
AutorDavor Miličić
AutorAhmed El-Sohemy
AutorVladimir Vuksan
MBZ: 53962
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Dietary inorganic nitrate lowers blood pressure (BP) in healthy individuals through improved nitric oxide (NO) bioavailability. However, there is limited evidence examining the long-term effects of dietary nitrate for managing hypertension. We aimed to determine whether the sustained intake of dietary nitrate improved BP and cardiovascular disease (CVD) risk factors in individuals with early-stage hypertension. The Dietary Nitrate (NO3) on BP and CVD Risk Factors (DINO3) Trial was a multi-center, double-blinded, parallel, randomized, controlled trial in participants with elevated BP. Participants were supplemented with high-nitrate (HN) (~400 mg nitrate) or low-nitrate (LN) vegetable powder (~50 mg nitrate) on top of their usual diets for 16 weeks. The primary outcome was office systolic BP at 16 weeks. The secondary outcomes were 24 h ambulatory BP, central BP, heart-rate-corrected augmentation index (AIx75), carotid–femoral pulse wave velocity (cf-PWV), lipids, and high-sensitivity C-reactive protein (hs-CRP). Sixty-six participants were randomized at baseline (39M:27F, age: 51.5 ± 10.8 years, BMI:27.9 ± 3.2 kg/m2). In an intention-to-treat analysis, no differences were observed between HN and LN groups in terms of office systolic BP at 16 weeks (3.91 ± 3.52 mmHg, p = 0.27) or secondary outcomes. In this exploratory study, sustained HN vegetable supplementation did not exhibit more favorable vascular effects than LN vegetable supplementation in individuals with elevated BP.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNutrients
Brojčani podacivol. 16, br. 17, 3018
e-ISSN2072-6643
DOIhttps://doi.org/10.3390/nu16173018
URN:NBNurn:nbn:hr:105:208378
Datum objave publikacije2024-09-06
URL dokumentahttps://www.mdpi.com/2072-6643/16/17/3018
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-20 09:19:39