prikaz prve stranice dokumenta Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
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Scientific paper - Original scientific paper
Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
Biomedicines, 12 (2024), 8; 1642. https://doi.org/10.3390/biomedicines12081642
Huljev Frković, Sanda; Jelušić, Marija; Crkvenac Gornik, Kristina; Rogić, Dunja; Frković, Marijan

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Huljev Frković, S., Jelušić, M., Crkvenac Gornik, K., Rogić, D. & Frković, M. (2024). Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis. Biomedicines, 12. (8). doi: 10.3390/biomedicines12081642

Huljev Frković, Sanda, et al. "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis." Biomedicines, vol. 12, no. 8, 2024. https://doi.org/10.3390/biomedicines12081642

Huljev Frković, Sanda, Marija Jelušić, Kristina Crkvenac Gornik, Dunja Rogić and Marijan Frković. "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis." Biomedicines 12, no. 8 (2024). https://doi.org/10.3390/biomedicines12081642

Huljev Frković, S., et al. (2024) 'Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis', Biomedicines, 12(8). doi: 10.3390/biomedicines12081642

Huljev Frković S, Jelušić M, Crkvenac Gornik K, Rogić D, Frković M. Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis. Biomedicines [Internet]. 2024 July 24 [cited 2025 April 25];12(8). doi: 10.3390/biomedicines12081642

S. Huljev Frković, M. Jelušić, K. Crkvenac Gornik, D. Rogić and M. Frković, "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis", Biomedicines, vol. 12, no. 8, July 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:537197. [Accessed: 25 April 2025]

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Metadata
Title (english)Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
AuthorSanda Huljev Frković
AuthorMarija Jelušić
AuthorKristina Crkvenac Gornik
AuthorDunja Rogić
AuthorMarijan Frković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
Because of the unpredictable efficacy of methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA), the possibility of a favourable outcome is reduced in more than 30% of patients. To investigate the possible influence of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) gene deletion polymorphisms on MTX efficacy in patients with JIA, we determined these polymorphisms in 63 patients with JIA who did not achieve remission and 46 patients with JIA who achieved remission during MTX therapy. No significant differences were observed in the distribution of single GSTM1 or GSTT1 deletion polymorphisms or their combination between the two groups: 58.7% to 63.5%; p = 0.567, 17.4% to 22.2%; p = 0.502, and 13% to 12.7%; p = 0.966, respectively. Our results suggest that GSTM1 and GSTT1 deletion polymorphisms do not influence the efficacy of MTX in patients with JIA. Additional studies are required to determine the possible influence of GST deletion polymorphisms on MTX efficacy in patients with JIA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 8, 1642
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12081642
URN:NBNurn:nbn:hr:105:537197
Publication2024-07-24
Document URLhttps://www.mdpi.com/2227-9059/12/8/1642
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-25 12:41:20