prikaz prve stranice dokumenta Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
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Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
Biomedicines, 12 (2024), 8; 1642. https://doi.org/10.3390/biomedicines12081642
Huljev Frković, Sanda; Jelušić, Marija; Crkvenac Gornik, Kristina; Rogić, Dunja; Frković, Marijan

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Huljev Frković, S., Jelušić, M., Crkvenac Gornik, K., Rogić, D. i Frković, M. (2024). Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis. Biomedicines, 12. (8). doi: 10.3390/biomedicines12081642

Huljev Frković, Sanda, et al. "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis." Biomedicines, vol. 12, br. 8, 2024. https://doi.org/10.3390/biomedicines12081642

Huljev Frković, Sanda, Marija Jelušić, Kristina Crkvenac Gornik, Dunja Rogić i Marijan Frković. "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis." Biomedicines 12, br. 8 (2024). https://doi.org/10.3390/biomedicines12081642

Huljev Frković, S., et al. (2024) 'Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis', Biomedicines, 12(8). doi: 10.3390/biomedicines12081642

Huljev Frković S, Jelušić M, Crkvenac Gornik K, Rogić D, Frković M. Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis. Biomedicines [Internet]. 24.07.2024. [pristupljeno 24.04.2025.];12(8). doi: 10.3390/biomedicines12081642

S. Huljev Frković, M. Jelušić, K. Crkvenac Gornik, D. Rogić i M. Frković, "Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis", Biomedicines, vol. 12, br. 8, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:537197. [Citirano: 24.04.2025.]

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Naslov (engleski)Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
AutorSanda Huljev Frković
AutorMarija Jelušić
AutorKristina Crkvenac Gornik
AutorDunja Rogić
AutorMarijan Frković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Because of the unpredictable efficacy of methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA), the possibility of a favourable outcome is reduced in more than 30% of patients. To investigate the possible influence of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) gene deletion polymorphisms on MTX efficacy in patients with JIA, we determined these polymorphisms in 63 patients with JIA who did not achieve remission and 46 patients with JIA who achieved remission during MTX therapy. No significant differences were observed in the distribution of single GSTM1 or GSTT1 deletion polymorphisms or their combination between the two groups: 58.7% to 63.5%; p = 0.567, 17.4% to 22.2%; p = 0.502, and 13% to 12.7%; p = 0.966, respectively. Our results suggest that GSTM1 and GSTT1 deletion polymorphisms do not influence the efficacy of MTX in patients with JIA. Additional studies are required to determine the possible influence of GST deletion polymorphisms on MTX efficacy in patients with JIA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 12, br. 8, 1642
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12081642
URN:NBNurn:nbn:hr:105:537197
Datum objave publikacije2024-07-24
URL dokumentahttps://www.mdpi.com/2227-9059/12/8/1642
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-25 12:41:20