Učestalost i lokalizacija okultnih regionalnih metastaza kod bolesnika s karcinomom usne šupljine

master's thesis

• Title (english): The incidence and localization of occult regional metastasis in patients with oral cavity carcinoma
• Author: Matija Rusan
• Mentor: Ivica Lukšić (mentor)
• Committee member: Narandža Aljinović-Ratković (predsjednik povjerenstva)
• Committee member: Željko Orihovac (član povjerenstva)
• Committee member: Ivica Lukšić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Maxillofacial Surgery and Dentistry); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Planocelularni karcinom usne šupljine jedan je od najučestalijih karcinoma glave i vrata. Epitelnog je podrijetla i najčešće se javlja u osoba koje puše cigarete i konzumiraju alkoholna pića, osobito žestoka. Primarni karcinom usne šupljine može se javiti na bilo kojem mjestu u usnoj šupljini, no najčešće zahvaća jezik, dno usne šupljine i retromolarno područje. Glavni put metastaziranja je limfogeni u regionalne limfne čvorove vrata. Zahvaćenost limfnih čvorova okultnim regionalnim metastazama vrlo je važan prognostički faktor. Ovisno o veličini i stadiju primarnog karcinoma usne šupljine preporuča se učiniti elektivnu disekciju vrata zbog rizika od pojave okultnih regionalnih metastaza. Cilj ovog retrospektivnog istraživanja bio je utvrditi učestalost i lokalizaciju okultnih regionalnih metastaza u bolesnika sa karcinomom usne šupljine. Istraživanje je retrospektivno i obuhvatilo je 82 bolesnika sa histološki verificiranim planocelularnim karcinomom usne šupljine u periodu od 5 godina (2007. – 2012.). Prema rezultatima ovog istraživanja učestalost okultnih regionalnih metastaza je bila 45,12%. Karcinom usne šupljine najčešće se dijagnosticira u T2 stadiju, a učestalost okultnih regionalnih metastaza u T2 stadiju je 36,84%. S porastom T stadija raste i vjerojatnost od pojave okultnih regionalnih metastaza. Najčešća lokalizacija okultnih regionalnih metastaza kod primarnog karcinoma usne šupljine bila je u regiji I vrata (56,76%).

Abstract (english)

Oral cavity squamous cell carcinoma is one of the most frequent cancers in the head and neck region. It is of epithelial origin and most commonly appears in people who smoke cigarettes and consume alcoholic drinks, especially spirit. The primary tumor can appear anywhere in the oral cavity, but three of the most common sublocalizations are tongue, floor of the mouth and retromolar area. The main metastatic path for squamous cell carcinoma of the oral cavity is lymphatic in the regional lymph nodes of the neck. Occult metastases in regional lymph nodes is the most important prognostic factor. Depending on the size and stage of the primary tumor, it is often recommended to make an elective neck dissection due to risk of regional occult metastases. The goal of this retrospective study was to determine the frequency and localization of occult regional metastasis in patients with oral squamous cell carcinoma. This retrospective study included 82 patients with histologically verified squamous cell carcinoma of the oral cavity during the 5-year period (2007-2012). According to the results of this study, the frequency of regional occult metastases was 45.12%. The most common pathological stage is T2 stage, and the incidence of regional occult metastases in T2 stage is 36.84%. With a higher T stage, the probability of regional occult metastasis increases. The most frequent localization of regional occult metastasis in oral squamous cell carcinoma was in the region I of the neck in 56,76% of patients.

• Keywords: planocelularni karcinom usne šupljine; regionalne okultne metastaze; elektivna disekcija vrata
• Keywords (english): squamous cell carcinoma in oral cavity; occult regional metastasis; elective neck dissection
• Language: croatian
• URN:NBN: urn:nbn:hr:105:525821
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-15 08:05:07