Tumori strome i spolnog tračka testisa

master's thesis

• Title (english): Sex cord and stromal tumors of the testis
• Author: Fran Čakar
• Mentor: Tihana Regović Džombeta (mentor)
• Committee member: Monika Ulamec (predsjednik povjerenstva)
• Committee member: Slavko Gašparov (član povjerenstva)
• Committee member: Tihana Regović Džombeta (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Urology

Abstract

Tumori testisa su heterogena skupina koja čini tek oko 1% svih tumora u muškaraca. Tumori testisa se najčešće javljaju u dobi nakon puberteta pa do 45. godine života te su stoga epidemiološki i klinički značajni. Trenutno važeća, službena klasifikacija tumora testisa je izdana 2016. godine u sklopu klasifikacije tumora mokraćnog i muškog spolnog sustava Svjetske zdravstvene organizacije (WHO, od engl. World Health Organization).
Najčešći tumori testisa su porijekla spolnih stanica testisa, a čine preko 90% svih tumora testisa. Ovi tumori imaju jedinstvenu histogenetsku osnovu jer svi potječu od intratubularne preinvazivne lezije koja se naziva in situ tumor spolnih stanica (GCNIS, od engl. Germ cell neoplasia in situ). Glavni predstavnik ove skupine tumora je seminom.
Sljedeći po učestalosti su tumori strome i spolnog tračka testisa s udjelom od oko 2-5%. Tumori ove skupine su histogenetski heterogeni; neki potječu od spolnog tračka, neki su stromalnog podrijetla, dok podrijetlo nekih tumora ove skupine još uvijek nije razjašnjeno. Glavni predstavnici ove skupine su tumori Leydigovih stanica i tumori Sertolijevih stanica.
U zadnje izdanje WHO klasifikacije tumora mokraćnog sustava i muških spolnih organa su uvršteni i neki novi tumori porijekla strome i spolnog tračka.
Cilj ovog rada bio je opisati tumore strome i spolnog tračka testisa prema WHO klasifikaciji iz 2016. godine, s epidemiološkog, kliničkog, morfološkog, imunohistokemijskog i citogenetskog stajališta te prikazati incidenciju tumora strome i spolnog tračka testisa u Kliničkom zavodu za patologiju i citologiju, „Ljudevit Jurak“, KBC Sestre milosrdnice u razdoblju od 1. siječnja 2011. do 20. svibnja 2019.

Abstract (english)

Testicular tumors are very heterogeneous and make approximately 1% of all tumors in male sex. Most testicular tumors occur from after the puberty until the middle age. This makes these tumors clinically, but also epidemiologically interesting and significant. Currently used and official classification of testicular tumors is WHO classification of tumors of the Urinary system and Male Genital Organs issued in year 2016.
The most common testicular tumors are germ cell tumors, which make approximately 90% of all testicular tumors. These tumors develop from the preinvasive intratubular lesion, called germ cell neoplasia in situ (GCNIS). The most common germ cell tumor is seminoma.
The second most common testicular tumors, after germ cell tumors, are sex cord and stromal tumors of the testis. They make approximately 2-5% of all testicular tumors. These tumors are histogenetically very heterogeneous; while some develop from sex-cord tissue, some from gonadal stroma, the tissue of origin of some is still unknown. The most common sex cord and stromal tumors of the testis are Leydig cell tumor and Sertoli cell tumor. Some additional, newly recognized tumors have been added to this group in the last WHO classification issued in 2016.
The aim of this study was to describe sex cord and stromal tumors of the testis and their most important epidemiological, clinical, morphological, immunohistochemical and cytogenetic features and also to present the incidence rate of sex-cord and stromal tumors of the testis at the Clinical Department of Pathology and Cytology, “Ljudevit Jurak”, Clinical hospital centre Sestre milosrdnice in period from 1 January 2011 to 20 May 2019.

• Keywords: tumori strome; tumori spolnog tračka testisa; tumori testisa; WHO klasifikacija
• Keywords (english): sex cord tumors; stromal tumors of the testis; testicular tumors; WHO classification
• Language: croatian
• URN:NBN: urn:nbn:hr:105:833322
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-11-21 12:46:17