Morfološke karakteristike dijabetičkog edema makule

master's thesis

• Title (english): Morphological features of diabetic macular edema
• Author: Josip Vratarić
• Mentor: Nenad Vukojević (mentor)
• Committee member: Tomislav Jukić (predsjednik povjerenstva)
• Committee member: Miro Kalauz (član povjerenstva)
• Committee member: Nenad Vukojević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Ophthalmology and Optometry); Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Ophthalmology

Abstract

Dijabetes je jedna od najčešćih bolesti u 21. stoljeću, a dijabetička retinopatija najčešća je i najpoznatija mikrovaskularna komplikacija šećerne bolesti. Dijabetički makularni edem najčešći je uzrok gubitka vidne oštrine u bolesnika s dijabetesom. Iako međusobno isprepleteni, DME može oštetiti vidnu oštrinu s ili bez prisustva ostalih znakova retinopatije. Također je moguća dugogodišnja prisutnost retinopatije kojoj se tek kasnije priključe znakovi DME-a.
Klinički parametri i morfološke karakteristike DME-a danas se vrlo efikasno određuju pomoću OCT-a. Pojavom OCT-a moglo se konačno pristupiti detaljnom proučavanju bolesti i lakšoj individualizaciji terapije za svakog pojedinog bolesnika.
Terapija DME-a također je ušla u novu eru. Dosadašnji tretmani laserskom fotokoagulacijom uvelike su zamijenjeni novih modalitetima liječenja poput intravitrealnih kortikosteroidnih implantata i anti-VEGF terapije.Također se i dalje ističe važnost dobre kontrole osnovne bolesti.
Bolje razumijevanje patofiziologije DME-a, novija i bolja dijagnostika kao i novi terapijski postupci daju nadu u još bolju prevenciju gubitka vidne funkcije u bolesnika sa šećernom bolešću.

Abstract (english)

Diabetes is one of the most common diseases in the 21st century. Diabetic retinopathy is the most common and most known microvascular complication of diabetes. Diabetic macular edema is the most common cause of visual acuity loss in patients with diabetes. Although tightly associated with each other, DME can occur with or without the presence of retinopathy. Another possibility is the long lasting presence of retinopathy with later signs of DME.
Today, the clinical parameters and morphological characteristics of DME are effectively assesed with OCT. With the presence of OCT there is finally a way to assess DME in detail and it's presence also made it easier to further individualize treatment for each and every patient.
A new era of DME therapy has started. Laser fotocoagulation is mainly becoming secondary to new treatment modalities such as intravitreal corticosteroid implants and anti-VEGF therapy. Though good and thorough management of the primary disease is still very important.
Better understanding of the patophysiology of DME,new and better diagnostics and new treatment modalities give us hope that we will soon be able to prevent vision function loss more efficiently in patients with diabetes.

• Keywords: DME; dijabetička retinopatija; OCT; anti-VEGF terapija
• Keywords (english): DME; diabetic retinopathy; OCT; anti-VEGF therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:762272
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-02-17 16:37:42