| Abstract | U ovom preglednom radu pokušali smo sažeti i pojasniti odnos između BPC 157 i NO
sustava, tte povezanost sa Moncadovim homeostatskim odgovorom (održanje
vaskularnog integriteta i kontrole na trombocitima) NO sustava na ozljedu. Naime BPC
157 osim određenog učinka cijeljenja isto tako utječe na sve događaje koji uslijede nakon
gubitka vaskularnog integriteta (ovisno o uvijetima on smanjuje trombozu ili smanjuje
krvarenje to jest trombocitopeniju), dok u cijelom nizu različitih modela ozljeda, akutnih ili
kroničnih, BPC 157 uvijek poboljšava proces cijeljenja stimulirajući ekspresiju egr-1 i naB2
gena. Hipoteza da se BPC 157 (pritom se konstitutivno stvara u želučanoj sluznici, uz već
poznatu važnost NO sintetaze i bazalnog nakupljanja NO-a u istoj sluznici) iskazuje
efektivnu kompeticiju sa L-argininom i njegovim analozima, i da je to sve od fiziološkog
značaja, ide u prilog blagotvornim učincima BPC 157 i njegovog uzajamnog odnosa sa NO
sustavom. Pri tome mislimo na njihovo međudjelovanje u zaštiti želučane sluznice
posljedično akutnim i kroničnim alkoholnim lezijama, u pogledu citoprotekcije, regulaciji
krvnog tlaka, kroničnom zatajenju srca, plićnoj hipertenziji, aritmijama, smetnji uzrokovanih
hipokalemijom i hiperkalemijom te naposljetku u cijeljenju kompleksnih ozljeda kao što su
kolokutane i ezofagokutane fistule. Međutim kako se ova sposobnost moduliranja NO
sustava može praktično preslikat u kliničke učinke, tek treba ustvrditi. |
| Abstract (english) | We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close
participation in Moncada's (maintained vascular integrity, platelets control) homeostatic
healing response of NO-system to injury. Namely, BPC 157 particular healing effect also
affects all events after vascular integrity loss (dependent on circumstances, it reduces
either thrombosis or bleeding/thrombocytopenia) and in a series of different injury models,
acute and chronic, BPC 157 consistently advances healing after severe injuries in various
tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high
safety. Hypothesis, that BPC 157 (since formed constitutively in the gastric mucosa, stable
in human gastric juice, along with significance of NO-synthase and the basal formation of
NO in stomach mucosa, greater than that seen in other tissues) exhibits a general,
effective competing both with L-arginine analogues and L-arginine, and that this has some
physiologic importance, later, practically supports its beneficial effects illustrating BPC 157
and NO-system mutual relations in gastric mucosa and mucosal protection, following
alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation;
alcohol acute/chronic intoxication, and withdrawal; cardiovascular disturbances, chronic
heart failure, pulmonary hypertension, and arrhythmias; disturbances after hypokalemia
and hyperkalemia, and potassium-cell membrane dysfunction; and finally, in complex
healing failure, proved by the fistulas healing, colocutaneous and esophagocutaneous.
However, how this advantage of modulating NO-system, may be practically translated into
an enhanced clinical performance remains to be determined. |
