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Scientific paper - Original scientific paper
A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system
Medical Hypotheses, 126 (2019); 38-41. https://doi.org/10.1016/j.mehy.2019.03.011
Meštrović, Tomislav; Wilson, Jonas; Ljubin-Sternak, Sunčanica; Sviben, Mario; Bedenić, Branka; Barać, Aleksandra; Neuberg, Marijana; Drenjančević, Domagoj; Ribić, Rosana; Kozina, Goran

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Meštrović, T., Wilson, J., Ljubin Sternak, S., Sviben, M., Bedenić, B., Barać, A. ... Kozina, G. (2019). A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system. Medical Hypotheses, 126., 38-41. doi: 10.1016/j.mehy.2019.03.011

Meštrović, Tomislav, et al. "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system." Medical Hypotheses, vol. 126, 2019, pp. 38-41. https://doi.org/10.1016/j.mehy.2019.03.011

Meštrović, Tomislav, Jonas Wilson, Sunčanica Ljubin Sternak, Mario Sviben, Branka Bedenić, Aleksandra Barać, Marijana Neuberg, Domagoj Drenjančević, Rosana Ribić and Goran Kozina. "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system." Medical Hypotheses 126 (2019): 38-41. https://doi.org/10.1016/j.mehy.2019.03.011

Meštrović, T., et al. (2019) 'A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system', Medical Hypotheses, 126, pp. 38-41. doi: 10.1016/j.mehy.2019.03.011

Meštrović T, Wilson J, Ljubin Sternak S, Sviben M, Bedenić B, Barać A, and sur.. A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system. Medical Hypotheses [Internet]. 2019 May [cited 2024 April 12];126:38-41. doi: 10.1016/j.mehy.2019.03.011

T. Meštrović, et al., "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system", Medical Hypotheses, vol. 126, pp. 38-41, May 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:168186. [Accessed: 12 April 2024]

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Metadata
Title (english)A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system
AuthorTomislav Meštrović
AuthorJonas Wilson
AuthorSunčanica Ljubin-Sternak
AuthorMario Sviben
AuthorBranka Bedenić
AuthorAleksandra Barać
AuthorMarijana Neuberg
AuthorDomagoj Drenjančević
AuthorRosana Ribić
AuthorGoran Kozina
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
The predominance of the genus Corynebacterium in the healthy male urogenital system contributes to the resident microbiome of not only the distal urethra, but potentially the proximal urethra and urinary bladder as well. However, for certain species in this genus, pathogenic potential was described, and the salient representative is Corynebacterium glucuronolyticum (C. glucuronolyticum) implicated in cases of urethritis and prostatitis in men. Nonetheless, some still question whether C. glucuronolyticum can actually be considered pathogenic or rather just a commensal species fortuitously isolated in patients with urogenital symptoms and/or syndromes. Although pathogen/commensal dichotomy is not always clear-cut, we hypothesize that specific genetic markers may expose C. glucuronolyticum as a convincingly pathogenic Corynebacterium. More specifically, characteristic pathogenic gene constellation inherent to this species (most notably the presence of specific sortase/SpaA-type pili gene clusters, but also the augmentative role of type VII secretion system) may significantly facilitate host tissue adhesion, with subsequent suppression/evasion of the immune response and acquisition of vitally important nutrients. Consequently, these genetic markers differentiate C. glucuronolyticum from its commensal counterparts, and give this species a pathogenic facet, which can be even further influenced by the Allee effect. In this paper we also propose a specific methodological approach on how to analyze C. glucuronolyticum epithelial colonization capacity and explore inceptive host cell-pathogen interactions that manipulate host environment and immune responses. This entails moving from approaches based primarily on overall homology of primary sequences towards specific structure-function studies to precisely evaluate all stakeholders involved in pili assemblage, cell adhesion and the expression of other virulence traits. In the era of high precision medicine, the hypothesized roles of C. glucuronolyticum adhesion systems in both virulence and nutrient acquisition may also reveal promising targets for future drug developments.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMedical Hypotheses
Numberingvol. 126, pp. 38-41
p-ISSN0306-9877
e-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2019.03.011
URN:NBNurn:nbn:hr:105:168186
Publication2019-05
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0306987719301069
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-02-15 09:17:48