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A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system
Medical Hypotheses, 126 (2019); 38-41. https://doi.org/10.1016/j.mehy.2019.03.011
Meštrović, Tomislav; Wilson, Jonas; Ljubin-Sternak, Sunčanica; Sviben, Mario; Bedenić, Branka; Barać, Aleksandra; Neuberg, Marijana; Drenjančević, Domagoj; Ribić, Rosana; Kozina, Goran

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Meštrović, T., Wilson, J., Ljubin Sternak, S., Sviben, M., Bedenić, B., Barać, A. ... Kozina, G. (2019). A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system. Medical Hypotheses, 126., 38-41. doi: 10.1016/j.mehy.2019.03.011

Meštrović, Tomislav, et al. "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system." Medical Hypotheses, vol. 126, 2019, str. 38-41. https://doi.org/10.1016/j.mehy.2019.03.011

Meštrović, Tomislav, Jonas Wilson, Sunčanica Ljubin Sternak, Mario Sviben, Branka Bedenić, Aleksandra Barać, Marijana Neuberg, Domagoj Drenjančević, Rosana Ribić i Goran Kozina. "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system." Medical Hypotheses 126 (2019): 38-41. https://doi.org/10.1016/j.mehy.2019.03.011

Meštrović, T., et al. (2019) 'A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system', Medical Hypotheses, 126, str. 38-41. doi: 10.1016/j.mehy.2019.03.011

Meštrović T, Wilson J, Ljubin Sternak S, Sviben M, Bedenić B, Barać A, i sur.. A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system. Medical Hypotheses [Internet]. 05.2019. [pristupljeno 10.10.2024.];126:38-41. doi: 10.1016/j.mehy.2019.03.011

T. Meštrović, et al., "A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system", Medical Hypotheses, vol. 126, str. 38-41, Svibanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:168186. [Citirano: 10.10.2024.]

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Naslov (engleski)A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system
AutorTomislav Meštrović
AutorJonas Wilson
AutorSunčanica Ljubin-Sternak
AutorMario Sviben
AutorBranka Bedenić
AutorAleksandra Barać
AutorMarijana Neuberg
AutorDomagoj Drenjančević
AutorRosana Ribić
AutorGoran Kozina
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
The predominance of the genus Corynebacterium in the healthy male urogenital system contributes to the resident microbiome of not only the distal urethra, but potentially the proximal urethra and urinary bladder as well. However, for certain species in this genus, pathogenic potential was described, and the salient representative is Corynebacterium glucuronolyticum (C. glucuronolyticum) implicated in cases of urethritis and prostatitis in men. Nonetheless, some still question whether C. glucuronolyticum can actually be considered pathogenic or rather just a commensal species fortuitously isolated in patients with urogenital symptoms and/or syndromes. Although pathogen/commensal dichotomy is not always clear-cut, we hypothesize that specific genetic markers may expose C. glucuronolyticum as a convincingly pathogenic Corynebacterium. More specifically, characteristic pathogenic gene constellation inherent to this species (most notably the presence of specific sortase/SpaA-type pili gene clusters, but also the augmentative role of type VII secretion system) may significantly facilitate host tissue adhesion, with subsequent suppression/evasion of the immune response and acquisition of vitally important nutrients. Consequently, these genetic markers differentiate C. glucuronolyticum from its commensal counterparts, and give this species a pathogenic facet, which can be even further influenced by the Allee effect. In this paper we also propose a specific methodological approach on how to analyze C. glucuronolyticum epithelial colonization capacity and explore inceptive host cell-pathogen interactions that manipulate host environment and immune responses. This entails moving from approaches based primarily on overall homology of primary sequences towards specific structure-function studies to precisely evaluate all stakeholders involved in pili assemblage, cell adhesion and the expression of other virulence traits. In the era of high precision medicine, the hypothesized roles of C. glucuronolyticum adhesion systems in both virulence and nutrient acquisition may also reveal promising targets for future drug developments.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMedical Hypotheses
Brojčani podacivol. 126, str. 38-41
p-ISSN0306-9877
e-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2019.03.011
URN:NBNurn:nbn:hr:105:168186
Datum objave publikacije2019-05
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0306987719301069
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-02-15 09:17:48