Helicobacter pylori u patogenezi malignih novotvorina želuca

master's thesis

• Title (english): Helicobacter pylori in pathogenesis of gastric malignant neoplasms
• Author: Martina Živković
• Mentor: Anita Škrtić (mentor)
• Committee member: Slavko Gašparov (predsjednik povjerenstva)
• Committee member: Lovorka Batelja-Vuletić (član povjerenstva)
• Committee member: Anita Škrtić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Helicobacter pylori (HP) je gram negativna mikroaerofilna bakterija koja kolonizira sluznicu želuca. Opstanak u nepovoljnim uvjetima kisele sredine želuca omogućuje joj sinteza ureaze koja katalizira proizvodnju amonijaka i ugljikova dioksida iz uree i neutralizira želučani pH. Kolonizacijom je zahvaćena približno polovica svjetske populacije, s većom prevalencijom u državama u razvoju, zbog čega se dovodi u vezu sa socioekonomskim statusom. U većini slučajeva kolonizacija dovodi do asimptomatske infekcije. Dugotrajna infekcija uzrokovana HP može rezultirati razvojem kroničnog gastritisa. Kronični atrofični gastritis čini prvi korak Correa kaskade koja predstavlja postepenu progresiju promjena na želučanoj sluznici koje vode nastanku karcinoma želuca. Navedene promjene uključuju atrofiju žljezdanog epitela, intestinalnu metaplaziju epitela i displaziju epitela. U patogenezi karcinoma želuca, osim bakterijskih faktora virulencije, važnu ulogu imaju osobine domaćina te okolišni čimbenici. Karcinom želuca je peti najčešći tumor u svijetu. Zbog odsutnosti kliničkih simptoma i posljedično kasne dijagnoze, karcinom želuca karakterizira visoka stopa mortaliteta. Probavni sustav je najčešće primarno sijelo ekstranodalnog non-Hodgkinovog limfoma. U otprilike dvije trećine slučajeva riječ je o želucu. HP infekcija predstavlja jedan od glavnih rizičnih čimbenika za razvoj primarnih limfoma želuca (PGL). Upalna reakcija posredovana HP inducira proliferaciju B-limfocita i stvaranje limfnih folikula unutar želučane sluznice. Tijekom vremena zbog nakupljenih genetskih promjena dolazi do autonomnog rasta klona B-stanica i nastanka limfoma. Eradikacija infekcije u velikog broja pacijenata smanjuje rizik za pojavu premalignih lezija, i čak vodi regresiji ranih stadija limfoma. Endoskopija i patohistološka dijagnoza predstavljaju standardni postupak u otkrivanju neoplazmi želuca.

Abstract (english)

Helicobacter pylori (HP) is a gram negative microaerobic bacterium that colonizes the gastric mucosa. Survival in adverse conditions of acidic gastric medium is enabled by urease synthesis, which catalyses production of ammonia and carbon dioxide from urea and neutralizes gastric pH. Colonization affects nearly half of the global population, with higher prevalence in developing countries, which is why it is related to socioeconomic status. In most cases colonization leads to asymptomatic infection. Long-term infection by HP may result in the development of chronic gastritis. The chronic atrophic gastritis makes the first step in Correa´s cascade, which represents a gradual progression of gastric mucosal changes that lead to the development of gastric carcinoma. That changes include glandular atrophy, intestinal metaplasia and dysplasia of the epitelium. Besides bacterial virulence factors, host properties and environmental factors play an important role in the pathogenesis of gastric carcinoma. Gastric carcinoma is the fifth most common cancer worldwide. Because of clinical symptom absence, and consequently late diagnosis, gastric carcinoma is characterized by high mortality rate. The digestive system is the most common primary site of extranodal non-Hodgkin lymphomas. The stomach makes approximately two-thirds of cases. HP infection represents one of the main risk factors for primary gastric lymphoma (PGL) development. Inflammatory reaction mediated by HP induces B-cell proliferation and lymphoid follicle formation within gastric mucosa. Over time, because of accumulated genetic changes, autonomous growth of B-cell clone occurs and lymphoma develops.
In a large number of patients, infection eradication decreases risk for premalignant lesion appearance, and even leads to early stage MALT lymphoma regression. Endoscopy and pathohistological diagnosis present standard procedure in gastric neoplasm finding.

• Keywords: Helicobacter pylori; kronični gastritis; karcinom želuca; primarni limfom želuca
• Keywords (english): Helicobacter pylori; chronic gastritis; gastric carcinoma; primary gastric lymphoma
• Language: croatian
• URN:NBN: urn:nbn:hr:105:218852
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-13 07:23:08