prikaz prve stranice dokumenta Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
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Scientific paper - Original scientific paper
Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
Psychiatry Research, 291 (2020); 113278. https://doi.org/10.1016/j.psychres.2020.113278
Konjevod, Marcela; Nikolac Perković, Matea; Švob Štrac, Dubravka; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Tudor, Lucija; Mimica, Ninoslav; Hirasawa-Fujita, Mika; Domino, Edward F; Pivac, Nela

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Konjevod, M., Nikolac Perković, M., Švob Štrac, D., Uzun, S., Nedić Erjavec, G., Kozumplik, O. ... Pivac, N. (2020). Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence. Psychiatry Research, 291.. doi: 10.1016/j.psychres.2020.113278

Konjevod, Marcela, et al. "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence." Psychiatry Research, vol. 291, 2020. https://doi.org/10.1016/j.psychres.2020.113278

Konjevod, Marcela, Matea Nikolac Perković, Dubravka Švob Štrac, Suzana Uzun, Gordana Nedić Erjavec, Oliver Kozumplik, Lucija Tudor, et al. "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence." Psychiatry Research 291 (2020). https://doi.org/10.1016/j.psychres.2020.113278

Konjevod, M., et al. (2020) 'Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence', Psychiatry Research, 291. doi: 10.1016/j.psychres.2020.113278

Konjevod M, Nikolac Perković M, Švob Štrac D, Uzun S, Nedić Erjavec G, Kozumplik O, and sur.. Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence. Psychiatry Research [Internet]. 2020 September [cited 2024 November 07];291. doi: 10.1016/j.psychres.2020.113278

M. Konjevod, et al., "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence", Psychiatry Research, vol. 291, September 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:304635. [Accessed: 07 November 2024]

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Metadata
Title (english)Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
AuthorMarcela Konjevod
AuthorMatea Nikolac Perković
AuthorDubravka Švob Štrac
AuthorSuzana Uzun
AuthorGordana Nedić Erjavec
AuthorOliver Kozumplik
AuthorLucija Tudor
AuthorNinoslav Mimica
AuthorMika Hirasawa-Fujita
AuthorEdward F Domino
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Tobacco smoking is highly prevalent in patients with schizophrenia and alcohol dependence. The underlying neurobiology of nicotine addiction is complex. Rewarding effects of nicotine from cigarettes are associated, among others, with mu-opioid receptors encoded by the OPRM1 gene. The aim of the study was to evaluate the association between two OPRM1 gene polymorphisms, rs1799971 and rs510769, and tobacco smoking in Caucasian patients with schizophrenia, alcohol dependence, and healthy control subjects. The study included 1058 Caucasians (277 patients with schizophrenia, 359 patients with alcohol dependence, and 422 healthy control subjects), subdivided according to the nicotine dependence into smokers (i.e. current smokers) and non-smokers. A significant association was found between the GC haplotype (OPRM1 rs1799971 and rs510769) and smoking in healthy controls, but not in patients with schizophrenia and alcohol dependence. A nominal association was detected in all cases/controls, but this significance did not survive the correction for the multiple testing. This is the first study to reveal that nicotine dependence is associated with the GC haplotype of the OPRM1 rs1799971 and rs510769 in all subjects or specifically in healthy controls. These results did not confirm the strong connection between OPRM1 polymorphisms and nicotine dependence in schizophrenia or alcohol dependence.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePsychiatry Research
Numberingvol. 291, 113278
p-ISSN0165-1781
e-ISSN1872-7123
DOIhttps://doi.org/10.1016/j.psychres.2020.113278
URN:NBNurn:nbn:hr:105:304635
Publication2020-09
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0165178120314074
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-10-01
Terms of useLicence In copyright icon
Created on2021-05-18 07:15:11