prikaz prve stranice dokumenta Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
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Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
Psychiatry Research, 291 (2020); 113278. https://doi.org/10.1016/j.psychres.2020.113278
Konjevod, Marcela; Nikolac Perković, Matea; Švob Štrac, Dubravka; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Tudor, Lucija; Mimica, Ninoslav; Hirasawa-Fujita, Mika; Domino, Edward F; Pivac, Nela

Citirajte ovaj rad

Konjevod, M., Nikolac Perković, M., Švob Štrac, D., Uzun, S., Nedić Erjavec, G., Kozumplik, O. ... Pivac, N. (2020). Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence. Psychiatry Research, 291.. doi: 10.1016/j.psychres.2020.113278

Konjevod, Marcela, et al. "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence." Psychiatry Research, vol. 291, 2020. https://doi.org/10.1016/j.psychres.2020.113278

Konjevod, Marcela, Matea Nikolac Perković, Dubravka Švob Štrac, Suzana Uzun, Gordana Nedić Erjavec, Oliver Kozumplik, Lucija Tudor, et al. "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence." Psychiatry Research 291 (2020). https://doi.org/10.1016/j.psychres.2020.113278

Konjevod, M., et al. (2020) 'Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence', Psychiatry Research, 291. doi: 10.1016/j.psychres.2020.113278

Konjevod M, Nikolac Perković M, Švob Štrac D, Uzun S, Nedić Erjavec G, Kozumplik O, i sur.. Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence. Psychiatry Research [Internet]. 09.2020. [pristupljeno 18.11.2024.];291. doi: 10.1016/j.psychres.2020.113278

M. Konjevod, et al., "Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence", Psychiatry Research, vol. 291, Rujan 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:304635. [Citirano: 18.11.2024.]

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Podaci o radu
Naslov (engleski)Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence
AutorMarcela Konjevod
AutorMatea Nikolac Perković
AutorDubravka Švob Štrac
AutorSuzana Uzun
AutorGordana Nedić Erjavec
AutorOliver Kozumplik
AutorLucija Tudor
AutorNinoslav Mimica
AutorMika Hirasawa-Fujita
AutorEdward F Domino
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Tobacco smoking is highly prevalent in patients with schizophrenia and alcohol dependence. The underlying neurobiology of nicotine addiction is complex. Rewarding effects of nicotine from cigarettes are associated, among others, with mu-opioid receptors encoded by the OPRM1 gene. The aim of the study was to evaluate the association between two OPRM1 gene polymorphisms, rs1799971 and rs510769, and tobacco smoking in Caucasian patients with schizophrenia, alcohol dependence, and healthy control subjects. The study included 1058 Caucasians (277 patients with schizophrenia, 359 patients with alcohol dependence, and 422 healthy control subjects), subdivided according to the nicotine dependence into smokers (i.e. current smokers) and non-smokers. A significant association was found between the GC haplotype (OPRM1 rs1799971 and rs510769) and smoking in healthy controls, but not in patients with schizophrenia and alcohol dependence. A nominal association was detected in all cases/controls, but this significance did not survive the correction for the multiple testing. This is the first study to reveal that nicotine dependence is associated with the GC haplotype of the OPRM1 rs1799971 and rs510769 in all subjects or specifically in healthy controls. These results did not confirm the strong connection between OPRM1 polymorphisms and nicotine dependence in schizophrenia or alcohol dependence.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPsychiatry Research
Brojčani podacivol. 291, 113278
p-ISSN0165-1781
e-ISSN1872-7123
DOIhttps://doi.org/10.1016/j.psychres.2020.113278
URN:NBNurn:nbn:hr:105:304635
Datum objave publikacije2020-09
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0165178120314074
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-10-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-05-18 07:15:11