Morphological variation of ulnar dimelia

master's thesis

• Title (croatian): Morfološka varijacija ulnarne dimelije
• Author: David Oscar Benjamin Schwarz
• Mentor: Krešimir Bulić (mentor)
• Committee member: Krešimir Bulić (predsjednik povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Committee member: Anko Antabak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Ulnar dimelia is a rare congenital disease with a characteristic range morphological of changes. These include duplication of the ulna, absence of the radius and polydactyly, although there is great variation of the changes seen in specific reports. Here I describe the main pathophysiological mechanisms, morphological variations as well as commonly used surgical strategies for this condition. For this purpose, I have screened the major databases to find the relevant literature and created a pooled analysis table for the morphological variations. The parameters used for the summarizing, include number of the upper limb fingers on the affected side, absence/presence of the thumb, type of the ulnar duplication, active and passive movement range, functional capability of the affected hand as well as the preceding events and the gender of the patient. For some of them I have discussed the surgical strategies and the long-term outcomes. All in all, this condition is characterized by a wide range of morphological variations. Further investigations should be performed to have a complete picture and strong classification algorithm for this extremely rare disease.

Abstract (croatian)

Ulnarna dimelija je rijetka kongenitalna bolest karakterističnog raspona morfoloških promjena. One uključuju dupliciranje ulne, odsutnost radijusa i polidaktiliju, iako postoje velike razlike u promjenama koje su opažene u određenim izvješćima. Ovdje opisujem glavne patofiziološke mehanizme, morfološke varijacije kao i uobičajene kirurške strategije za ovo stanje. U tu svrhu pregledao sam glavne baze podataka da bih pronašao relevantnu literaturu i stvorio zbirnu analiznu tablicu za morfološke varijacije. Parametri korišteni za rezimiranje uključuju broj prstiju gornjih udova na zahvaćenoj strani, odsutnost / prisustvo palca, vrstu ulnarne duplikacije, raspon aktivnog i pasivnog pokreta, funkcionalnu sposobnost zahvaćene ruke kao i prethodne događaje i spol bolesnika. Za neke od njih sam raspravljao o kirurškim strategijama i dugoročnim ishodima.. Sve u svemu, ovo stanje karakterizira širok raspon morfoloških varijacija. Potrebno je provesti daljnja ispitivanja kako bi se stvorila cjelovita slika i algoritam za klasifikaciju ove izuzetno rijetke bolesti.

• Keywords: ulnar dimelia; congenital disease; polydactyly
• Keywords (croatian): ulnarna dimelija; urođena bolest; polidaktilija
• Language: english
• URN:NBN: urn:nbn:hr:105:353195
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-08 09:10:46