prikaz prve stranice dokumenta Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
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Scientific paper - Original scientific paper
Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
Biomolecules, 11 (2021), 5; 641. https://doi.org/10.3390/biom11050641
Nedić Erjavec, Gordana; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Šagud, Marina; Kozumplik, Oliver; Švob Štrac, Dubravka; Peraica, Tina; Mimica, Ninoslav; Havelka Meštrović, Ana; Žilić, Denis; Pivac, Nela

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Nedić Erjavec, G., Nikolac Perković, M., Tudor, L., Uzun, S., Kovačić Petrović, Z., Konjevod, M. ... Pivac, N. (2021). Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules, 11. (5). doi: 10.3390/biom11050641

Nedić Erjavec, Gordana, et al. "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans." Biomolecules, vol. 11, no. 5, 2021. https://doi.org/10.3390/biom11050641

Nedić Erjavec, Gordana, Matea Nikolac Perković, Lucija Tudor, Suzana Uzun, Zrnka Kovačić Petrović, Marcela Konjevod, Marina Šagud, et al. "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans." Biomolecules 11, no. 5 (2021). https://doi.org/10.3390/biom11050641

Nedić Erjavec, G., et al. (2021) 'Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans', Biomolecules, 11(5). doi: 10.3390/biom11050641

Nedić Erjavec G, Nikolac Perković M, Tudor L, Uzun S, Kovačić Petrović Z, Konjevod M, and sur.. Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules [Internet]. 2021 April 26 [cited 2024 December 21];11(5). doi: 10.3390/biom11050641

G. Nedić Erjavec, et al., "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans", Biomolecules, vol. 11, no. 5, April 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:651325. [Accessed: 21 December 2024]

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Metadata
Title (english)Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perković
AuthorLucija Tudor
AuthorSuzana Uzun
AuthorZrnka Kovačić Petrović
AuthorMarcela Konjevod
AuthorMarina Šagud
AuthorOliver Kozumplik
AuthorDubravka Švob Štrac
AuthorTina Peraica
AuthorNinoslav Mimica
AuthorAna Havelka Meštrović
AuthorDenis Žilić
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Posttraumatic stress disorder (PTSD) is frequently associated with cognitive disturbances and high prevalence of smoking. This study evaluated cognition in war veterans with PTSD and control subjects, controlled for the effect of smoking and brain derived neurotrophic factor (BDNF) rs6265 and rs56164415 genotypes/alleles. Study included 643 male war veterans with combat related PTSD and 120 healthy controls. Genotyping was done by real time PCR. Cognitive disturbances were evaluated using the Positive and Negative Syndrome Scale (PANSS) cognition subscale and the Rey-Osterrieth Complex Figure (ROCF) test scores. Diagnosis (p < 0.001), BDNF rs56164415 (p = 0.011) and smoking (p = 0.028) were significant predictors of the cognitive decline in subjects with PTSD. BDNF rs56164415 T alleles were more frequently found in subjects with PTSD, smokers and non-smokers, with impaired cognition, i.e., with the higher PANSS cognition subscale scores and with the lower ROCF immediate recall test scores. Presence of one or two BDNF rs56164415 T alleles was related to cognitive decline in PTSD. The T allele carriers with PTSD had advanced cognitive deterioration in smokers and nonsmokers with PTSD, and worse short-term visual memory function. Our findings emphasize the role of the BDNF rs56164415 T allele and smoking in cognitive dysfunction in war veterans with PTSD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 11, no. 5, 641
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom11050641
URN:NBNurn:nbn:hr:105:651325
Publication2021-04-26
Document URLhttps://www.mdpi.com/2218-273X/11/5/641
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-05 12:34:37