prikaz prve stranice dokumenta Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
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Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
Biomolecules, 11 (2021), 5; 641. https://doi.org/10.3390/biom11050641
Nedić Erjavec, Gordana; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Šagud, Marina; Kozumplik, Oliver; Švob Štrac, Dubravka; Peraica, Tina; Mimica, Ninoslav; Havelka Meštrović, Ana; Žilić, Denis; Pivac, Nela

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Nedić Erjavec, G., Nikolac Perković, M., Tudor, L., Uzun, S., Kovačić Petrović, Z., Konjevod, M. ... Pivac, N. (2021). Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules, 11. (5). doi: 10.3390/biom11050641

Nedić Erjavec, Gordana, et al. "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans." Biomolecules, vol. 11, br. 5, 2021. https://doi.org/10.3390/biom11050641

Nedić Erjavec, Gordana, Matea Nikolac Perković, Lucija Tudor, Suzana Uzun, Zrnka Kovačić Petrović, Marcela Konjevod, Marina Šagud, et al. "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans." Biomolecules 11, br. 5 (2021). https://doi.org/10.3390/biom11050641

Nedić Erjavec, G., et al. (2021) 'Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans', Biomolecules, 11(5). doi: 10.3390/biom11050641

Nedić Erjavec G, Nikolac Perković M, Tudor L, Uzun S, Kovačić Petrović Z, Konjevod M, i sur.. Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules [Internet]. 26.04.2021. [pristupljeno 07.10.2024.];11(5). doi: 10.3390/biom11050641

G. Nedić Erjavec, et al., "Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans", Biomolecules, vol. 11, br. 5, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:651325. [Citirano: 07.10.2024.]

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Podaci o radu
Naslov (engleski)Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans
AutorGordana Nedić Erjavec
AutorMatea Nikolac Perković
AutorLucija Tudor
AutorSuzana Uzun
AutorZrnka Kovačić Petrović
AutorMarcela Konjevod
AutorMarina Šagud
AutorOliver Kozumplik
AutorDubravka Švob Štrac
AutorTina Peraica
AutorNinoslav Mimica
AutorAna Havelka Meštrović
AutorDenis Žilić
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Posttraumatic stress disorder (PTSD) is frequently associated with cognitive disturbances and high prevalence of smoking. This study evaluated cognition in war veterans with PTSD and control subjects, controlled for the effect of smoking and brain derived neurotrophic factor (BDNF) rs6265 and rs56164415 genotypes/alleles. Study included 643 male war veterans with combat related PTSD and 120 healthy controls. Genotyping was done by real time PCR. Cognitive disturbances were evaluated using the Positive and Negative Syndrome Scale (PANSS) cognition subscale and the Rey-Osterrieth Complex Figure (ROCF) test scores. Diagnosis (p < 0.001), BDNF rs56164415 (p = 0.011) and smoking (p = 0.028) were significant predictors of the cognitive decline in subjects with PTSD. BDNF rs56164415 T alleles were more frequently found in subjects with PTSD, smokers and non-smokers, with impaired cognition, i.e., with the higher PANSS cognition subscale scores and with the lower ROCF immediate recall test scores. Presence of one or two BDNF rs56164415 T alleles was related to cognitive decline in PTSD. The T allele carriers with PTSD had advanced cognitive deterioration in smokers and nonsmokers with PTSD, and worse short-term visual memory function. Our findings emphasize the role of the BDNF rs56164415 T allele and smoking in cognitive dysfunction in war veterans with PTSD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 11, br. 5, 641
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom11050641
URN:NBNurn:nbn:hr:105:651325
Datum objave publikacije2021-04-26
URL dokumentahttps://www.mdpi.com/2218-273X/11/5/641
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-05 12:34:37