prikaz prve stranice dokumenta Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results
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Scientific paper - Original scientific paper
Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results
PLOS ONE, 16 (2021), 6; e0253468. https://doi.org/10.1371/journal.pone.0253468
Popović Grle, Sanja; Lampalo, Marina; Škrinjarić Cincar, Sanda; Bulat Kardum, Ljiljana; Gudelj, Ivan; Basioli Kasap, Eugenija; Vergles, Mirna; Tudorić, Neven

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Popović Grle, S., Lampalo, M., Škrinjarić Cincar, S., Bulat Kardum, Lj., Gudelj, I., Basioli Kasap, E. ... Tudorić, N. (2021). Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results. PLOS ONE, 16. (6). doi: 10.1371/journal.pone.0253468

Popović Grle, Sanja, et al. "Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results." PLOS ONE, vol. 16, no. 6, 2021. https://doi.org/10.1371/journal.pone.0253468

Popović Grle, Sanja, Marina Lampalo, Sanda Škrinjarić Cincar, Ljiljana Bulat Kardum, Ivan Gudelj, Eugenija Basioli Kasap, Mirna Vergles and Neven Tudorić. "Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results." PLOS ONE 16, no. 6 (2021). https://doi.org/10.1371/journal.pone.0253468

Popović Grle, S., et al. (2021) 'Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results', PLOS ONE, 16(6). doi: 10.1371/journal.pone.0253468

Popović Grle S, Lampalo M, Škrinjarić Cincar S, Bulat Kardum Lj, Gudelj I, Basioli Kasap E, and sur.. Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results. PLOS ONE [Internet]. 2021 June 29 [cited 2025 April 01];16(6). doi: 10.1371/journal.pone.0253468

S. Popović Grle, et al., "Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results", PLOS ONE, vol. 16, no. 6, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181041. [Accessed: 01 April 2025]

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Metadata
Title (english)Attitudes of Croatian pulmonologists concerning obstacles to earlier, more appropriate use of biologics in severe asthma: Survey results
AuthorSanja Popović Grle
AuthorMarina Lampalo
AuthorSanda Škrinjarić Cincar
AuthorLjiljana Bulat Kardum
AuthorIvan Gudelj
AuthorEugenija Basioli Kasap
AuthorMirna Vergles
AuthorNeven Tudorić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims: Biologics have been proven efficacious for patients with severe asthma (SA). It is essential to diagnose such individuals correctly. This study was designed to survey pulmonologists to identify barriers to early diagnosis and subsequent appropriate use of biologics for SA in Croatia. ----- Methods: A pulmonologist group with expertise in SA developed the initial list of questions, with the final questionnaire created according to a 2-round Delphi method. The resulting survey consisted... More of 23 items consequently divided into 4 domains: 1) Pulmonologists' demographics and professional experiences; 2) Concerns about asthma management; 3) Attitudes toward SA diagnosis; and 4) Beliefs and attitudes regarding the use of biologics in managing SA. The given answers represented the respondents' estimates. ----- Results: Eighty-four surveys were analyzed, with pulmonologists observing that general practitioners often inaccurately diagnose asthma and treat acute exacerbations. Although specialist centers are capably and correctly equipped, the time to diagnose patients with SA is approximately 3.5 months, with initial use of biologics delayed an additional 2 months. The primary indications for prescribing biologics are conventional therapy with oral glucocorticoids (91.7%) and frequent acute exacerbations (82.1%). In addition to improper diagnosis (64.3%), many patients with SA do not receive the indicated biologics owing to strict administrative directives for reimbursement (70.2%) or limited hospital resources (57.1%). ----- Limitations: The limitations of this survey include the subjective nature of the collected data, the relatively small sample size, and the lack of the biologic efficacy evaluation. ----- Conclusions: Croatian pulmonologists observed that a significant number of patients with SA who are eligible for biologics are not prescribed them, largely because of an inaccurate and/or delayed diagnosis, a delayed referral to a specialist center, highly restrictive criteria for reimbursement, and/or institutional budgetary limitations. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLOS ONE
Numberingvol. 16, no. 6, e0253468
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0253468
URN:NBNurn:nbn:hr:105:181041
Publication2021-06-29
Document URLhttps://dx.plos.org/10.1371/journal.pone.0253468
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-26 09:56:44
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