Psorijaza i rizik infarkta srca i mozga

master's thesis

• Title (english): Myocardial Infarction and stroke risk in patiens with psoriasis
• Author: Katarina Radoš
• Mentor: Edvard Galić (mentor)
• Committee member: Romana Čeović (predsjednik povjerenstva)
• Committee member: Željko Duić (član povjerenstva)
• Committee member: Edvard Galić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Psorijaza je česta kronična sistemska bolest od koje boluje najmanje 100 milijuna ljudi diljem svijeta. Smatra se da se pojavljuje u genski podložnih pojedinaca u kojih kao okidač djeluju određeni čimbenici iz okoliša. Patofiziologija je kompleksna i uključuje složenu interakciju urođenog i stečenog imunosnog sustava. Klinička slika obilježena je pojavom eritematoznih žarišta prekrivenih ljuskama na predilekcijskim mjestima kao što su ekstenzorne strane udova. Uz psorijazu se javljaju značajni komorbiditeti koji mogu imati velik utjecaj na kvalitetu života te čak i skratiti životni vijek, a uključuju psorijatični artritis, depresiju, metabolički sindrom i kardiovaskularne bolesti. Posljednjih desetljeća intenzivno se istražuje povezanost infarkta srca i mozga sa psorijazom. Povećana incidencija velikih kardiovaskularnih i cerebrovaskularnih događaja, koji uključuju infarkt miokarda i moždani udar, kod bolesnika sa psorijazom može se objasniti pomoću više mehanizama. Bolesnici sa psorijazom često imaju veću prevalenciju klasičnih čimbenika rizika za ova životno ugrožavajuća stanja u odnosu na opću populaciju, uključujući povećanu tjelesnu masu i pretilost, šećernu bolest, hiperlipidemiju i hipertenziju. Također, patofiziologija psorijaze obuhvaća aktiviranje upalnih mehanizama, koji imaju ključnu ulogu i u razvoju ateroskleroze. Sve je veći broj radova koji upućuju na psorijazu kao neovisni čimbenik rizika za razvoj moždanog i srčanog udara.

Abstract (english)

Psoriasis is a common, chronic systemic disease affecting at least 100 million people worldwide. It is presumed that psoriasis occurs in genetically susceptible individuals in whom specific environmental factors act as a trigger. Pathophysiology is complex and includes interactions between the innate and adaptive immune systems. Clinical presentation is characterized by erythematous lesions covered by scales on predilection sites such as extensor surfaces. There are some comorbidities that can develop with psoriasis and have a major impact on the quality of life, including psoriatic arthritis, depression, metabolic syndrome and cardiovascular disease. In the last few decades there has been increased interest in discovering the link between psoriasis and heart and brain ischemia. Higher incidence of major cardiovascular and cerebrovascular events, which include myocardial infarction and stroke, can be explained by several mechanisms. Patients with psoriasis tend to have higher prevalence of traditional risk factors for these life-threatening states, including higher body max index, obesity, diabetes, hyperlipidaemia and hypertension. Moreover, pathophysiology of psoriasis includes activation of inflammatory mechanisms, which have a pivotal role in the development of atherosclerosis. There is mounting evidence that psoriasis is an independent risk factor for myocardial infarction and stroke.

• Keywords: psorijaza; infarkt miokarda; moždani udar
• Keywords (english): psoriasis; myocardial infarction; stroke
• Language: croatian
• URN:NBN: urn:nbn:hr:105:594984
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-04 08:59:56