Lobularni karcinom dojke

master's thesis

• Title (english): Lobular breast cancer
• Author: Darko Ceković
• Mentor: Davor Tomas (mentor)
• Committee member: Monika Ulamec (predsjednik povjerenstva)
• Committee member: Lovorka Batelja-Vuletić (član povjerenstva)
• Committee member: Davor Tomas (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Lobularni karcinom dojke (drugi naziv: invazivni lobularni karcinom) je vrsta raka dojke koji se razvija u mliječnim žlijezdama (lobulima) dojke. Lobularni karcinom je drugi najčešći tip raka dojke; na njega otpada otprilike 10 do 15 posto svih invazivnih karcinoma dojke.
Može se prezentirati različitim simptomima, kao što su oteklina cijele ili jednog dijela dojke, iritacija kože, stvaranje malih rupica na koži (može podsjećati na narančinu koru), bol u dojci ili u području bradavice, iscjedak iz dojke, crvenilo, zadebljanje ili ljuštenje kože dojke ili bradavice te pojava kvržice ili otekline u području pazuha.
Prvi korak u dijagnosticiranju lobularnog karcinoma dojke jest uzimanje detaljne anamneze i klinički pregled pacijenta, nakon čega slijede radiološke dijagnostičke metode, kao što su mamografija, ultrazvuk dojke i magnetna rezonancija. Ako se pomoću tih metoda uoči abnormalnost, izvodi se biopsija dojke širokom iglom radi potvrde nalaza.
Prognoza i liječenje lobularnog karcinoma dojke ovisi u kojem stadiju je bolest dijagnosticirana, pri čemu se koristi TNM klasifikacijski sustav (stadiji 1 - 4). Metode liječenja uključuju kiruršku resekciju (bilo cijele dojke ili samo dijela u kojem se nalazi tumor), kemoterapiju i radioterapiju, hormonsku terapiju, ciljanu terapiju te imunoterapiju.

Abstract (english)

Lobular breast cancer (also called invasive lobular carcinoma) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It is the second most common type of breast cancer, accounting for 10 to 15 percent of all invasive breast cancers.
It presents with a wide variety of symptoms, including swelling of all or part of the breast, skin irritation, skin dimpling (sometimes looking like an orange peel), breast or nipple pain, nipple discharge, redness, scaliness or thickening of the nipple or breast skin or a lump or swelling of the underarm area.
The first step in diagnosing lobular breast cancer is patient examination and detailed history taking, which is followed by radiological imaging, including mammography, ultrasound and magnetic resonance imaging (MRI). If an abnormality is detected, core needle biopsy is performed to confirm the findings.
The prognosis and treatment of lobular breast cancer depends on the stage of the disease, which is primarily determined by using the TNM staging system (stages 1 - 4). Methods of treatment include surgical resection (either the whole breast or exclusively the part where the tumor is located), chemotherapy and radiotherapy, hormonal therapy, targeted therapy and immunotherapy.

• Keywords: rak dojke; lobularni karcinom; stadij; dijagnostika; liječenje
• Keywords (english): breast cancer; lobular cancer; stage; diagnostics; treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:500738
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-04 10:49:51