prikaz prve stranice dokumenta Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
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Scientific paper - Original scientific paper
Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
Scientific Reports, 12 (2022), 1; 11649. https://doi.org/10.1038/s41598-022-14931-2
Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Erjavec, Igor; Smajlović, Ana; Milešević, Marina; Karlović, Sven; Capak, Hrvoje; Vrbanac, Zoran; Matičić, Dražen; Vukičević, Slobodan

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Štoković, N., Ivanjko, N., Pećin, M., Erjavec, I., Smajlović, A., Milešević, M. ... Vukičević, S. (2022). Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics. Scientific Reports, 12. (1). doi: 10.1038/s41598-022-14931-2

Štoković, Nikola, et al. "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics." Scientific Reports, vol. 12, no. 1, 2022. https://doi.org/10.1038/s41598-022-14931-2

Štoković, Nikola, Natalia Ivanjko, Marko Pećin, Igor Erjavec, Ana Smajlović, Marina Milešević, Sven Karlović, et al. "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics." Scientific Reports 12, no. 1 (2022). https://doi.org/10.1038/s41598-022-14931-2

Štoković, N., et al. (2022) 'Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics', Scientific Reports, 12(1). doi: 10.1038/s41598-022-14931-2

Štoković N, Ivanjko N, Pećin M, Erjavec I, Smajlović A, Milešević M, and sur.. Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics. Scientific Reports [Internet]. 2022 July 08 [cited 2024 April 19];12(1). doi: 10.1038/s41598-022-14931-2

N. Štoković, et al., "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics", Scientific Reports, vol. 12, no. 1, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:740925. [Accessed: 19 April 2024]

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Metadata
Title (english)Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
AuthorNikola Štoković
AuthorNatalia Ivanjko
AuthorMarko Pećin
AuthorIgor Erjavec
AuthorAna Smajlović
AuthorMarina Milešević
AuthorSven Karlović
AuthorHrvoje Capak
AuthorZoran Vrbanac
AuthorDražen Matičić
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (Osteogrow) is a novel therapeutic solution for bone regeneration. This study is aimed to investigate the long-term outcome of ABGS with synthetic ceramics (Osteogrow-C) in rabbit posterolateral spinal fusion (PLF) model. Osteogrow-C implants were implanted bilaterally between rabbit lumbar transverse processes. We compared the outcome following implantation of ABGS with ceramic particles of different chemical composition (TCP and biphasic ceramics containing both TCP and HA) and size (500-1700 µm and 74-420 µm). Outcome was analyzed after 14 and 27 weeks by microCT, histology, and biomechanical analyses. Successful bilateral spinal fusion was observed in all animals at the end of observation period. Chemical composition of ceramic particles has impact on the PLF outcome via resorption of TCP ceramics, while ceramics containing HA were only partially resorbed. Moreover, persistence of ceramic particles subsequently resulted with an increased bone volume in implants with small particles containing high proportion of HA. ABGS (rhBMP6/ABC) with various synthetic ceramic particles promoted spinal fusion in rabbits. This is the first presentation of BMP-mediated ectopic bone formation in rabbit PLF model with radiological, histological, and biomechanical features over a time course of up to 27 weeks.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 12, no. 1, 11649
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-022-14931-2
URN:NBNurn:nbn:hr:105:740925
Publication2022-07-08
Document URLhttps://www.nature.com/articles/s41598-022-14931-2
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-21 09:34:39