prikaz prve stranice dokumenta Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
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Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
Scientific Reports, 12 (2022), 1; 11649. https://doi.org/10.1038/s41598-022-14931-2
Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Erjavec, Igor; Smajlović, Ana; Milešević, Marina; Karlović, Sven; Capak, Hrvoje; Vrbanac, Zoran; Matičić, Dražen; Vukičević, Slobodan

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Štoković, N., Ivanjko, N., Pećin, M., Erjavec, I., Smajlović, A., Milešević, M. ... Vukičević, S. (2022). Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics. Scientific Reports, 12. (1). doi: 10.1038/s41598-022-14931-2

Štoković, Nikola, et al. "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics." Scientific Reports, vol. 12, br. 1, 2022. https://doi.org/10.1038/s41598-022-14931-2

Štoković, Nikola, Natalia Ivanjko, Marko Pećin, Igor Erjavec, Ana Smajlović, Marina Milešević, Sven Karlović, et al. "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics." Scientific Reports 12, br. 1 (2022). https://doi.org/10.1038/s41598-022-14931-2

Štoković, N., et al. (2022) 'Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics', Scientific Reports, 12(1). doi: 10.1038/s41598-022-14931-2

Štoković N, Ivanjko N, Pećin M, Erjavec I, Smajlović A, Milešević M, i sur.. Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics. Scientific Reports [Internet]. 08.07.2022. [pristupljeno 19.12.2024.];12(1). doi: 10.1038/s41598-022-14931-2

N. Štoković, et al., "Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics", Scientific Reports, vol. 12, br. 1, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:740925. [Citirano: 19.12.2024.]

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Podaci o radu
Naslov (engleski)Long-term posterolateral spinal fusion in rabbits induced by rhBMP6 applied in autologous blood coagulum with synthetic ceramics
AutorNikola Štoković
AutorNatalia Ivanjko
AutorMarko Pećin
AutorIgor Erjavec
AutorAna Smajlović
AutorMarina Milešević
AutorSven Karlović
AutorHrvoje Capak
AutorZoran Vrbanac
AutorDražen Matičić
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (Osteogrow) is a novel therapeutic solution for bone regeneration. This study is aimed to investigate the long-term outcome of ABGS with synthetic ceramics (Osteogrow-C) in rabbit posterolateral spinal fusion (PLF) model. Osteogrow-C implants were implanted bilaterally between rabbit lumbar transverse processes. We compared the outcome following implantation of ABGS with ceramic particles of different chemical composition (TCP and biphasic ceramics containing both TCP and HA) and size (500-1700 µm and 74-420 µm). Outcome was analyzed after 14 and 27 weeks by microCT, histology, and biomechanical analyses. Successful bilateral spinal fusion was observed in all animals at the end of observation period. Chemical composition of ceramic particles has impact on the PLF outcome via resorption of TCP ceramics, while ceramics containing HA were only partially resorbed. Moreover, persistence of ceramic particles subsequently resulted with an increased bone volume in implants with small particles containing high proportion of HA. ABGS (rhBMP6/ABC) with various synthetic ceramic particles promoted spinal fusion in rabbits. This is the first presentation of BMP-mediated ectopic bone formation in rabbit PLF model with radiological, histological, and biomechanical features over a time course of up to 27 weeks.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 12, br. 1, 11649
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-022-14931-2
URN:NBNurn:nbn:hr:105:740925
Datum objave publikacije2022-07-08
URL dokumentahttps://www.nature.com/articles/s41598-022-14931-2
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-21 09:34:39