Elastografske vrijednosti tkiva dojke u žena

doctoral thesis

• Title (english): Elastographic values of breast tissue in women
• Author: Martina Džoić Dominković
• Mentor: Gordana Ivanac (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2017-03-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Uvod: Elastografija je nova UZV metoda koja se do sada upotrebljavala za lakšu BIRADS kategorizaciju sumnjivih lezija. Svrha našeg rada je bila procijeniti elastografsku tvrdoću normalnog tkiva dojke, njenu povezanost s mamografski i ultrazvučno procijenjenom gustoćom tkiva dojke te odrediti povezanost s faktorima rizika za karcinom dojke te faktorima koji utječu na mamografsku tvrdoću.
Materijali i metode: Proveli smo prospektivno istraživanje u koje smo uključili 200 žena različite dobi. Sve žene su ispunile upitnik s pitanjima o osobnoj, obiteljskoj i reproduktivnoj anamnezi. 100 žena je imalo priložene mamografske slike za usporedbu te su bile podijeljene u 4 skupine prema mamografskoj gustoći tkiva. Svim ženama se učinio UZV pregled u B-modu i elastografija u živom vremenu. Svakoj ženi se dodijelila i UZV skupina prema gustoći tkiva. U svakom kvadrantu dojke izmjerila se tvrdoća žljezdanog parenhima i masnog tkiva. Zatim smo izračunali prosječne elastografske vrijednosti tkiva dojke, usporedili ih s MMG i UZV procijenjenom gustoćom tkiva te s određenim kliničko-anamnestičkim parametrima.
Rezultati: Elastografske vrijednosti žljezdanog tkiva (66,4 kPa) su veće od elastografskih vrijednosti masnog tkiva (26,1 kPa) u svim kvadrantima i u obje dojke. Najniže elastografske vrijednosti su izmjerene u DLK, dok su vrijednosti lijeve dojke značajno veće u odnosu na desnu. Elastografske vrijednosti žljezdanog tkiva pozitivno koreliraju s mastalgijom i brojem nađenih benignih promjena u dojkama, a negativno s dobi, brojem trudnoća i BMI. Elastografske vrijednosti masnog tkiva negativno koreliraju s dobi i indeksom tjelesne mase. Elastografske vrijednosti žljezdanog i masnog tkiva pozitivno koreliraju s mamografskim i ultrazvučnim skupina prema gustoći tkiva.
Zaključci: Naše istraživanje je pokazalo povezanost tvrdoće tkiva dojke i njezine gustoće, to znači kako je žene moguće svrstati u skupinu onih s višim ili nižim rizikom za dobivanje karcinoma dojke metodom koja je brza, jeftina i bez ionizirajućeg zračenja. Ova bi studija mogla pridonijeti proširivanju indikacija za upotrebu elastografije u kliničkoj praksi.

Abstract (english)

Introduction: Breast elastography is a new ultrasound method for easier BIRADS categorization of the suspect lesions. Aim of this study is to estimate the elasticity of normal breast tissue and to compare it to the estimated mammographic and ultrasound breast density, also to correlate it with some well-known breast cancer risk factors and factors that influence on mammographic density.
Materials and methods: A prospective study with 200 women of different age was performed. All women fulfilled questionary about personal, familiar and reproductive history. A hundred women that had attached mammographic images were placed in one of four groups according to estimated mammographic density. The next step was an ultrasound examination with B-mod and elastography. One of three groups according to ultrasound density was assigned to all women. Elasticity of breast parenchyma and fatty tissue in all breast quadrants was measured. Average elastographic values of breast tissue were calculated and compared to estimated mammographic and ultrasound density, also to personal history factors.
Results: Elasticity of normal breast parenchyma (66,4 kPa) was higher than fatty tissue (26,1 kPa) in all breast quadrants and in both breasts. Lower outer quadrant of breasts had the lowest elasticity values of both parenchyma and fat. A left breast had higher elasticity values of breast tissue, comparing to a right breast. Glandular elasticity positively correlates with mastalgia and number of benign breast lesions. It negatively correlates with age, number of pregnancies and body mass index (BMI). Fat tissue elasticity negatively correlates with age and BMI. Glandular and fat tissue elasticity positively correlates with mammographic and ultrasound estimated breast density.
Conclusions: There is good correlation between breast elasticity and breast density. It means that the women could be classified in one of the groups with lower or higher breast cancer risk without ionizing radiation, also with the method which is fast and cheap. This study could contribute to widen indications for elastography in routine clinical practice.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:773890
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 97 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:44:33