prikaz prve stranice dokumenta Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
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Scientific paper - Original scientific paper
Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
ESC Heart Failure, 10 (2023), 2; 1054-1065. https://doi.org/10.1002/ehf2.14261
Radhoe, Sumant P.; Jakus, Nina; Veenis, Jesse F.; Timmermans, Philippe; Pouleur, Anne‐Catherine; Rubís, Pawel; Van Craenenbroeck, Emeline M.; Gaizauskas, Edvinas; Barge‐Caballero, Eduardo; Paolillo, Stefania; Grundmann, Sebastian; D'Amario, Domenico; Braun, Oscar Ö.; Gkouziouta, Aggeliki; Planinć, Ivo; Ljubas Maček, Jana; Meyns, Bart; Droogne, Walter; Wierzbicki, Karol; Holcman, Katarzyna; Flammer, Andreas J.; Gašparović, Hrvoje; Biočina, Bojan; Miličić, Davor; Lund, Lars H.; Ruschitzka, Frank; Brugts, Jasper J.; Čikes, Maja More authors...

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Radhoe, S. P., Jakus, N., Veenis, J. F., Timmermans, P., Pouleur, A., Rubís, P. ... Čikes, M. (2023). Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry. ESC Heart Failure, 10. (2), 1054-1065. doi: 10.1002/ehf2.14261

Radhoe, Sumant P., et al. "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry." ESC Heart Failure, vol. 10, no. 2, 2023, pp. 1054-1065. https://doi.org/10.1002/ehf2.14261

Radhoe, Sumant P., Nina Jakus, Jesse F. Veenis, Philippe Timmermans, Anne‐Catherine Pouleur, Pawel Rubís, Emeline M. Van Craenenbroeck, et al. "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry." ESC Heart Failure 10, no. 2 (2023): 1054-1065. https://doi.org/10.1002/ehf2.14261

Radhoe, S. P., et al. (2023) 'Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry', ESC Heart Failure, 10(2), pp. 1054-1065. doi: 10.1002/ehf2.14261

Radhoe SP, Jakus N, Veenis JF, Timmermans P, Pouleur A, Rubís P, and sur.. Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry. ESC Heart Failure [Internet]. 2023 April [cited 2024 December 09];10(2):1054-1065. doi: 10.1002/ehf2.14261

S. P. Radhoe, et al., "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry", ESC Heart Failure, vol. 10, no. 2, pp. 1054-1065, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:291988. [Accessed: 09 December 2024]

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Metadata
Title (english)Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
AuthorSumant P. Radhoe
AuthorNina Jakus
AuthorJesse F. Veenis
AuthorPhilippe Timmermans
AuthorAnne‐Catherine Pouleur
AuthorPawel Rubís
AuthorEmeline M. Van Craenenbroeck
AuthorEdvinas Gaizauskas
AuthorEduardo Barge‐Caballero
AuthorStefania Paolillo
AuthorSebastian Grundmann
AuthorDomenico D'Amario
AuthorOscar Ö. Braun
AuthorAggeliki Gkouziouta
AuthorIvo Planinć
AuthorJana Ljubas Maček
AuthorBart Meyns
AuthorWalter Droogne
AuthorKarol Wierzbicki
AuthorKatarzyna Holcman
AuthorAndreas J. Flammer
AuthorHrvoje Gašparović
AuthorBojan Biočina
AuthorDavor Miličić
AuthorLars H. Lund
AuthorFrank Ruschitzka
AuthorJasper J. Brugts
AuthorMaja Čikes
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow-up duration was 344 [range 147-823] days for women and 435 [range 190-816] days for men (P = 0.40). No significant sex-related differences were found in all-cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50-1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33-0.95]) but more often experienced right ventricular failure. No significant sex-related differences were found in other outcomes. Conclusions: In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. Additional research in female patients is warranted.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleESC Heart Failure
Numberingvol. 10, no. 2, pp. 1054-1065
p-ISSN2055-5822
e-ISSN2055-5822
DOIhttps://doi.org/10.1002/ehf2.14261
URN:NBNurn:nbn:hr:105:291988
Publication2023-04
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/ehf2.14261
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-05-16 07:48:44