prikaz prve stranice dokumenta Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
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Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
ESC Heart Failure, 10 (2023), 2; 1054-1065. https://doi.org/10.1002/ehf2.14261
Radhoe, Sumant P.; Jakus, Nina; Veenis, Jesse F.; Timmermans, Philippe; Pouleur, Anne‐Catherine; Rubís, Pawel; Van Craenenbroeck, Emeline M.; Gaizauskas, Edvinas; Barge‐Caballero, Eduardo; Paolillo, Stefania; Grundmann, Sebastian; D'Amario, Domenico; Braun, Oscar Ö.; Gkouziouta, Aggeliki; Planinć, Ivo; Ljubas Maček, Jana; Meyns, Bart; Droogne, Walter; Wierzbicki, Karol; Holcman, Katarzyna; Flammer, Andreas J.; Gašparović, Hrvoje; Biočina, Bojan; Miličić, Davor; Lund, Lars H.; Ruschitzka, Frank; Brugts, Jasper J.; Čikes, Maja Više autora...

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Radhoe, S. P., Jakus, N., Veenis, J. F., Timmermans, P., Pouleur, A., Rubís, P. ... Čikes, M. (2023). Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry. ESC Heart Failure, 10. (2), 1054-1065. doi: 10.1002/ehf2.14261

Radhoe, Sumant P., et al. "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry." ESC Heart Failure, vol. 10, br. 2, 2023, str. 1054-1065. https://doi.org/10.1002/ehf2.14261

Radhoe, Sumant P., Nina Jakus, Jesse F. Veenis, Philippe Timmermans, Anne‐Catherine Pouleur, Pawel Rubís, Emeline M. Van Craenenbroeck, et al. "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry." ESC Heart Failure 10, br. 2 (2023): 1054-1065. https://doi.org/10.1002/ehf2.14261

Radhoe, S. P., et al. (2023) 'Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry', ESC Heart Failure, 10(2), str. 1054-1065. doi: 10.1002/ehf2.14261

Radhoe SP, Jakus N, Veenis JF, Timmermans P, Pouleur A, Rubís P, i sur.. Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry. ESC Heart Failure [Internet]. 04.2023. [pristupljeno 15.10.2024.];10(2):1054-1065. doi: 10.1002/ehf2.14261

S. P. Radhoe, et al., "Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry", ESC Heart Failure, vol. 10, br. 2, str. 1054-1065, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:291988. [Citirano: 15.10.2024.]

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Naslov (engleski)Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
AutorSumant P. Radhoe
AutorNina Jakus
AutorJesse F. Veenis
AutorPhilippe Timmermans
AutorAnne‐Catherine Pouleur
AutorPawel Rubís
AutorEmeline M. Van Craenenbroeck
AutorEdvinas Gaizauskas
AutorEduardo Barge‐Caballero
AutorStefania Paolillo
AutorSebastian Grundmann
AutorDomenico D'Amario
AutorOscar Ö. Braun
AutorAggeliki Gkouziouta
AutorIvo Planinć
AutorJana Ljubas Maček
AutorBart Meyns
AutorWalter Droogne
AutorKarol Wierzbicki
AutorKatarzyna Holcman
AutorAndreas J. Flammer
AutorHrvoje Gašparović
AutorBojan Biočina
AutorDavor Miličić
AutorLars H. Lund
AutorFrank Ruschitzka
AutorJasper J. Brugts
AutorMaja Čikes
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow-up duration was 344 [range 147-823] days for women and 435 [range 190-816] days for men (P = 0.40). No significant sex-related differences were found in all-cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50-1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33-0.95]) but more often experienced right ventricular failure. No significant sex-related differences were found in other outcomes. Conclusions: In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. Additional research in female patients is warranted.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaESC Heart Failure
Brojčani podacivol. 10, br. 2, str. 1054-1065
p-ISSN2055-5822
e-ISSN2055-5822
DOIhttps://doi.org/10.1002/ehf2.14261
URN:NBNurn:nbn:hr:105:291988
Datum objave publikacije2023-04
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/ehf2.14261
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2023-05-16 07:48:44