Specifičnosti građe osteohondralne jedinice acetabuluma, neoacetabuluma i glave femura u bolesnika sa sekundarnom koksartrozom prouzročenom razvojnim poremećajem kuka

doctoral thesis

• Title (english): Specificities in the structure of osteochondral unit of acetabulum, neoacetabulum and femoral head in patients with secondary coxarthrosis induced by developmental dysplasia of the hip
• Author: Tea Duvančić
• Mentor: Domagoj Delimar (mentor)
• Committee member: Maja Prutki (predsjednik povjerenstva)
• Committee member: Dražen Matičić (član povjerenstva)
• Committee member: Vedran Katavić (član povjerenstva)
• Committee member: Ivan Bohaček (član povjerenstva)
• Committee member: Tomislav Đapić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-06-05, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics
• Universal decimal classification (UDC): 617 - Surgery. Orthopaedics. Ophthalmology

Abstract

Razvojni poremećaj kuka (DDH) jedan je od glavnih uzroka sekundarne koksartroze, koja je karakterizirana sličnim degenerativnim promjenama kao i primarna koksartroza. Cilj ovog istraživanja bio je odrediti građu osteohondralne jedinice acetabuluma, neoacetabuluma i glave femura bolesnika s DDH-om, bolesnika s primarnom koksartrozom i u normalnoj hrskavici. Po dva uzorka osteohondralne jedinice prikupljena su za vrijeme ugradnje totalne endoproteze kuka s acetabuluma, neoacetabuluma, nosivog i nenosivog dijela glave femura bolesnika s DDH-om, te s acetabuluma i glave femura pacijenata s primarnom koksartrozom i pacijenata sa subkapitalnim prijelomom vrata femura. Jedan od uzoraka je snimljen metodama mikromagnetske rezonancije i mikrokompjuterizirane tomografije, a drugi je obojan histološkim bojama i imunohistokemijskim bojenjem na kolagene tipa I, II, VI i X, te agrekan. Rezultati svih metoda uspoređeni su između i unutar istraživanih skupina. Rezultati ovog istraživanja pokazali su postojanje hijaline hrskavice na neoacetabulumu i acetabulumu pacijenata s DDH-om. Potvrđen je dio hipoteze koji tvrdi kako građa osteohondralne jedinice neoacetabuluma i glave femura bolesnika s DDH-om odgovara onoj degenerativne koksartroze. Osteohondralna jedinica acetabuluma i nenosivog dijela glave femura pacijenata s DDH-om građom nalikuje objema kontrolnim skupinama. Ovo je ujedno prvi put da je hrskavica neoacetabuluma pacijenata s visokim stupnjevima DDH-a detaljno histološki i radiološki okarakterizirana.

Abstract (english)

Developmental dysplasia of the hip (DDH) is the most common cause of secondary coxarthrosis, characterised by similar degenerative changes as primary coxarthrosis. This study aimed to characterise the structure of the osteochondral unit of patients with DDH, primary coxarthrosis and subcapital femoral neck fracture. Two samples of the osteochondral unit were taken from acetabula, neoacetabula, weight-bearing and non-weight bearing parts of the femoral heads of patients with DDH, and from acetabula and femoral heads of patients with primary coxarthrosis and subcapital femoral neck fractures. One sample was scanned on micro-MRI and micro-CT machines, and the other was stained with histological and immunohistochemical stains. Results of all the methods were compared between and within groups of patients. The results proved the existence of hyaline cartilage in neoacetabula and acetebula of DDH patients. Part of the hypothesis that claims the structure of the osteochondral unit of neoacetabulum and the femoral head of patients with DDH corresponds to that of degenerative coxarthrosis was confirmed. The osteochondral units of acetabula and the non-weight bearing part of the femoral heads of patients with DDH are similar to both control groups. This is the first time the cartilage of neoacetabula of DDH patients has been characterized.

• Keywords: Osteoartritis; kuk; Acetabulum; Hijalinska hrskavica; Glava bedrene kosti; Prijelomi vrata bedrene kosti; Magnetska rezonancija
• Keywords (english): Osteoarthritis; Hip; Acetabulum; Hyaline Cartilage; Femur Head; Femoral Neck Fractures; Magnetic Resonance Imaging
• Language: croatian
• URN:NBN: urn:nbn:hr:105:280175
• Promotion: 2023
• Project: Number: IP-2018-01-3688; Title: Karakterizacija hrskavice acetabuluma i femura u odraslih bolesnika s razvojnim poremećajem kuka; Acronym: HIPoCART; Leader: Domagoj Delimar; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 116 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-06-16 12:22:10