prikaz prve stranice dokumenta A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database
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Scientific paper - Original scientific paper
A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database
European Journal of Cardio-Thoracic Surgery, 63 (2023), 2; ezac514. https://doi.org/10.1093/ejcts/ezac514
Arabkhani, Bardia; Klautz, Robert J M; de Heer, Frederiek; De Kerchove, Laurent; El Khoury, Gebrine; Lansac, Emmanuel; Schäfers, Hans-Joachim; El-Hamamsy, Ismail; Lenoir, Marien; Aramendi, José I; Meuris, Bart; Verbrugghe, Peter; Kluin, Jolanda; Koolbergen, Dave R; Bouchot, Olivier; Rudež, Igor; Kolesar, Adrian; van Brakel, Thomas J More authors...

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Arabkhani, B., Klautz, R. J. M., de Heer, F., De Kerchove, L., El Khoury, G., Lansac, E. ... van Brakel, T. J. (2023). A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database. European Journal of Cardio-Thoracic Surgery, 63. (2). doi: 10.1093/ejcts/ezac514

Arabkhani, Bardia, et al. "A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database." European Journal of Cardio-Thoracic Surgery, vol. 63, no. 2, 2023. https://doi.org/10.1093/ejcts/ezac514

Arabkhani, Bardia, Robert J M Klautz, Frederiek de Heer, Laurent De Kerchove, Gebrine El Khoury, Emmanuel Lansac, Hans Joachim Schäfers, et al. "A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database." European Journal of Cardio-Thoracic Surgery 63, no. 2 (2023). https://doi.org/10.1093/ejcts/ezac514

Arabkhani, B., et al. (2023) 'A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database', European Journal of Cardio-Thoracic Surgery, 63(2). doi: 10.1093/ejcts/ezac514

Arabkhani B, Klautz RJM, de Heer F, De Kerchove L, El Khoury G, Lansac E, and sur.. A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database. European Journal of Cardio-Thoracic Surgery [Internet]. 2023 February 03 [cited 2025 March 17];63(2). doi: 10.1093/ejcts/ezac514

B. Arabkhani, et al., "A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database", European Journal of Cardio-Thoracic Surgery, vol. 63, no. 2, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:621141. [Accessed: 17 March 2025]

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Metadata
Title (english)A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database
AuthorBardia Arabkhani
AuthorRobert J M Klautz
AuthorFrederiek de Heer
AuthorLaurent De Kerchove
AuthorGebrine El Khoury
AuthorEmmanuel Lansac
AuthorHans-Joachim Schäfers
AuthorIsmail El-Hamamsy
AuthorMarien Lenoir
AuthorJosé I Aramendi
AuthorBart Meuris
AuthorPeter Verbrugghe
AuthorJolanda Kluin
AuthorDave R Koolbergen
AuthorOlivier Bouchot
AuthorIgor Rudež
AuthorAdrian Kolesar
AuthorThomas J van Brakel
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Objectives: Our goal was to evaluate the outcome of valve-sparing root replacement (VSRR) and to compare the outcomes to those of patients having composite valve-graft conduit aortic root replacement (CVG-ARR) in a cohort of patients with aortic root aneurysm ± valve insufficiency, without valvular stenosis. Although valve-sparing procedures are preferable in young patients, there is a lack of comparative data in comparable patients. Methods: The VSRR procedures were performed in 2005 patients, and 218 patients underwent a CVG-ARR procedure. Exclusion criteria included aortic dissection, endocarditis and valvular stenosis. Propensity score matching (3:1 ratio) was applied to compare VSRR (reimplantation 33% and remodelling 67%) and CVG-ARR. Results: We matched 218 patients with CVG-ARR to 654 patients with VSRR (median age, 56.0; median follow-up was 4 years in both groups; interquartile range 1-5 years). Early mortality was 1.1% of those who had VSRR versus 2.3% in those who had CVG-ARR. Survival was 95.4% [95% confidence interval (CI) 94-97%] at 5 years in patients who had VSRR versus 85.4% (95% CI 82-92%) in those who had CVG-ARR; P = 0.002. Freedom from reintervention at 5 years was 96.8% (95% CI 95-98%) with VSRR and 95.4% (95% CI 91-99%) with CVG-ARR (P = 0.98). Additionally, there were more thromboembolic, endocarditis and bleeding events in the patients who had CVG-ARR (P = 0.02). Conclusions: This multicentre study shows excellent results after valve-sparing root replacement in patients with an ascending aortic aneurysm with or without valve insufficiency. Compared to composite valve-graft aortic root replacement, survival is better and valve-related events are fewer. Consequently, valve-sparing procedures should be considered whenever a durable repair is feasible. We advocate a valve-sparing strategy even in more complex cases when performed in experienced centres.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Cardio-Thoracic Surgery
Numberingvol. 63, no. 2, ezac514
e-ISSN1873-734X
DOIhttps://doi.org/10.1093/ejcts/ezac514
URN:NBNurn:nbn:hr:105:621141
Publication2023-02-03
Document URLhttps://academic.oup.com/ejcts/article/doi/10.1093/ejcts/ezac514/6779980
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-08-17 11:54:23