Surgical treatment of liver metastases

master's thesis

• Title (croatian): Kirurško liječenje metastatskih tumora jetre
• Author: Gaja Tolić
• Mentor: Igor Petrović (mentor)
• Committee member: Igor Petrović (predsjednik povjerenstva)
• Committee member: Hrvoje Silovski (član povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Liver metastases (LM) are a heterogenous group of secondary neoplasms that originate from various primary sites but share a common pathway of metastasizing. From a surgical perspective, colorectal carcinoma (CRC) is the most significant tumor that disseminates to the liver, due to a high global burden of this disease, but also because of a significant potential for survival with a successful hepatic resection. Neuroendocrine tumors, and noncolorectal, nonneuroendocrine tumors also commonly disseminate to the liver and have potential for surgical treatment.

A retrospective study of patients who underwent hepatic resection of liver metastases was conducted at the Department of Surgery of the University Hospital Center Zagreb.

The goal of the study was to compare surgical strategies for patients with liver metastases who were treated at the University Hospital Center Zagreb from January 1st, 2017, until December 31st, 2021.

The highest proportion of liver resections (75,8%) was for colorectal cancer liver metastases. Patients were diagnosed with LM either metachronously or synchronously, and with a right- or left-sided primary tumor. Resection margins and the embryologic origin of the primary tumor demonstrated the clearest impact on survival, while resections of synchronous and metachronous LM showed comparable survival rates.

Abstract (croatian)

Metastaze u jetri su heterogena skupina sekundarnih neoplazmi koje potječu iz različitih primarnih sijela, ali imaju zajednički put metastaziranja. Iz kirurške perspektive, kolorektalni karcinom je najznačajniji tumor koji se širi u jetru, zbog velikog globalnog opterećenja ovom bolešću, ali i zbog značajnog potencijala za preživljavanje uz uspješnu resekciju jetre. Neuroendokrini tumori i ne-kolorektalni, ne-neuroendokrini tumori također se često šire u jetru i imaju potencijal za kirurško liječenje.

Na Klinici za kirurgiju KBC-a Zagreb provedena je retrospektivna studija pacijenata kojima je učinjena resekcija jetrenih metastaza.

Cilj istraživanja bio je usporediti kirurške strategije za pacijente s metastazama u jetri koji su liječeni u KBC-u Zagreb od 1. siječnja 2017. do 31. prosinca 2021.

Najveći udio resekcija jetre (75,8%) bio je zbog jetrenih metastaza kolorektalnog karcinoma. Pacijentima su metastaze na jetri dijagnosticirane metakrono ili sinkrono, te primarni tumor s desne ili lijeve strane. Resekcijski rubovi i embriološko podrijetlo primarnog tumora pokazali su najjasniji utjecaj na preživljenje, dok su resekcije sinkronih i metakronih metastaza pokazale usporedive stope preživljenja.

• Keywords: liver; metastasis; hepatectomy; colorectal carcinoma; neuroendocrine tumor
• Keywords (croatian): hepatektomija; jetra; kolorektalni karcinom; metastaza; neuroendokrini tumor
• Language: english
• URN:NBN: urn:nbn:hr:105:278861
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-01 12:18:38